Know Their Pain | Down Study 2011: Quantitative Sensory Testing and pain behaviour of subjects with Down*s syndrome compared to healthy controls

Completed

• Conditions: 10083624; Down's syndrome; Trisomy 21

• Registration Number: NL-OMON36235
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 156

Inclusion Criteria

Down*s syndrome group:
- Confirmed trisomy 21
- Age 8 to 30 years ;Control group:
- Sibling of participant with Down*s syndrome
- Age 8 to 30 years

Exclusion Criteria

- Developmental age lower than 5 years
- Insufficient understanding of the concepts of warm and cold sensation
- Diagnosis of migraine
- Treatment with antidepressants
- Treatment with anticonvulsants
- Treatment with analgesics <24 hours before study visit

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Sensory testing part 1: Correct sensations of cold, warmth, light touch, and<br /><br>sharpness.<br /><br>- Sensory testing part 2: Correct sensations of touch (Neuropen) and warm /<br /><br>cold (Rolltemp)<br /><br>- Sensory testing part 3: Detection threshold (touch) by Von Frey hairs.<br /><br>Detection and pain thresholds (warm and cold) in degrees Celsius (Thermal<br /><br>Sensory Analyzer).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>