Cohort Study on the Effects of Aging in Acquired Brain Injury Patients
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Acquired Brain Injury
- Sponsor
- University Medical Center Groningen
- Enrollment
- 800
- Locations
- 2
- Primary Endpoint
- Prevalence of the ABI-effect
- Last Updated
- 3 years ago
Overview
Brief Summary
A prospective cohort study (questionnaires), with an embedded case control study (neuropsychological assessments) in which the data is gathered within a timeframe of 3 years. A group of 700 patients and a group of 100 healthy volunteers will be participating.
Detailed Description
In the Netherlands an estimated 650.000 people live with the daily consequences of an Acquired Brain Injury (ABI). A substantial amount of these patients acquired their brain injury (traumatic brain injury, subarachnoid hemorrhage or cerebrovascular accident) at a relatively young age: between 18 and 50 years old. The chain-of-care for ABI aims for recovery in the subacute phase, usually within a period of one year after injury. After an adaptation period, the patients reach a new balance, with stabilization of complaints and reintegration, sometimes with the necessity of modifications. The group of patients who acquired a brain injury at a young age, have to face the effects of aging like decreased cognitive functions, which can cause the participation level to drop. This is called the ABI-effect in the current study. At this moment, insufficient information is available about the functioning of people who suffered ABI multiple years ago and have established a new balance, and now make the transition to an older phase of live. Primary objective: Explore the prevalence of the ABI-effect, by mapping the participation level. Secondary objective: Substantiate the occurence of the ABI-effect, by mapping cognitive functions of patients and compare these to healthy controls. Tertiary objective: Gain insight in the need of care for patients, to enhance regular care after ABI.
Investigators
Joukje van der Naalt
Prof. dr. J. van der Naalt
University Medical Center Groningen
Eligibility Criteria
Inclusion Criteria
- •Current age range between 50-67 years \[Rationale: having an age that enables the patient to experience the effects of aging with a low risk of neurodegenerative disease\]
- •Able to complete questionnaires independently
- •Additionally, patients must also meet the following criteria:
- •Age of acquiring the ABI ≧ 25 years \[Rationale: the brain is supposed to be fully developed at a maximum capacity
- •ABI must be ≧ 5 years ago\] \[Rationale :time period regarded sufficient to have achieved a stable level of cognitive functioning and participation after an ABI\]
- •ABI diagnosis at hospital admission with abnormalities at the brain-CT or MRI
- •Independent regarding Activities of Daily Living
- •Not living in a long-term care facility
Exclusion Criteria
- •Psychiatric disease (for which participant is currently treated)
- •Accompanying disease with reduced life expectancy
- •Neurological disease (including recurrent ABI for patients)
- •Language barriers prohibiting and completion of Dutch questionnaires
- •Alcohol or drug abuse
- •Suspected neurodegenerative disease
Outcomes
Primary Outcomes
Prevalence of the ABI-effect
Time Frame: A minimum of 5 years after ABI
The percentage of patients experiencing the ABI-effect. Also, a 95% confidence interval of this prevalence will be calculated.
Secondary Outcomes
- Cognitive functions of patients and healthy volunteers(A minimum of 5 years after ABI for patients)