Evaluation of Continuous Renal Replacement Therapy Circuit Lifespan in Intensive Care Patients: A Retrospective Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 162
- 试验地点
- 1
- 主要终点
- Maximum Transmembrane Pressure Across CRRT Circuit Lifespan Categories
研究概览
简要总结
The goal of this retrospective observational study is to evaluate how long continuous renal replacement therapy (CRRT) circuits remain in use in adult intensive care unit patients and to describe how CRRT pressure measurements change over time. The main questions it aims to answer are:
Are higher maximum and mean transmembrane pressure (TMP) values associated with longer CRRT circuit lifespan? Do time-normalized pressure trajectories and cumulative TMP burden differ between circuits with different lifespans? Do access pressure patterns influence the relationship between pressure measurements and circuit lifespan? Researchers will analyze archived CRRT device log files, including access pressure, filter pressure, effluent pressure, return pressure, and TMP measurements. No additional procedures, interventions, or study visits will be required. No directly identifiable patient information will be included in the analytical dataset.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Archived CRRT treatment sessions performed in adult intensive care unit patients.
- •CRRT sessions recorded on the Prismaflex platform and available as LOX device log files.
- •Sessions with a circuit lifespan of at least 1 hour, defined as the time between the first and last valid pressure recording.
- •Sessions containing sufficient time-stamped pressure data for analysis, including at least 60 valid pressure measurements.
- •Sessions with available pressure recordings for the relevant variables, including transmembrane pressure, access pressure, filter pressure, effluent pressure, and/or return pressure.
- •Sessions with adequate data integrity and chronologically interpretable pressure records.
排除标准
- •CRRT sessions with a runtime of less than 1 hour.
- •Sessions with missing pressure tables.
- •Sessions with fewer than 60 pressure measurements.
- •Sessions with missing or incomplete primary device records.
- •Sessions with missing timestamps or pressure records that cannot be ordered chronologically.
- •Sessions with inadequate pressure-data density for trajectory analysis.
- •Sessions with major data-integrity problems that prevent reliable calculation of circuit lifespan or pressure-derived variables.
- •Duplicate or otherwise unusable device-log records.
研究组 & 干预措施
CRRT Circuit Lifespan ≥48 Hours
CRRT sessions with a circuit lifespan of 48 hours or longer, defined as the time between the first and last valid pressure recording in the device log. No intervention was assigned.
干预措施: Archived CRRT Device Log Data (Other)
CRRT Circuit Lifespan <12 Hours
CRRT sessions with a circuit lifespan of less than 12 hours, defined as the time between the first and last valid pressure recording in the device log. No intervention was assigned.
干预措施: Archived CRRT Device Log Data (Other)
CRRT Circuit Lifespan 12 to <24 Hours
CRRT sessions with a circuit lifespan of at least 12 hours but less than 24 hours, defined as the time between the first and last valid pressure recording in the device log. No intervention was assigned.
干预措施: Archived CRRT Device Log Data (Other)
CRRT Circuit Lifespan 24 to <48 Hours
CRRT sessions with a circuit lifespan of at least 24 hours but less than 48 hours, defined as the time between the first and last valid pressure recording in the device log. No intervention was assigned.
干预措施: Archived CRRT Device Log Data (Other)
结局指标
主要结局
Maximum Transmembrane Pressure Across CRRT Circuit Lifespan Categories
时间窗: From the first to the last valid pressure recording of each CRRT session
To compare maximum transmembrane pressure values among CRRT sessions grouped by circuit lifespan: less than 12 hours, 12 to less than 24 hours, 24 to less than 48 hours, and 48 hours or longer.
次要结局
- Initial 6-hour TMP slope(During the first 6 hours of each CRRT session)
研究者
Arif Timuroğlu, MD
anesthesiology specialist, M.D.
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital