Dual-task Training Combined With tDCS on Cognitive-motor Performance and Brain Activity in Stroke Patients
- Conditions
- StrokeCortical Excitability
- Registration Number
- NCT06769672
- Lead Sponsor
- The Hong Kong Polytechnic University
- Brief Summary
The purpose of this study is to evaluate tDCS combined with cognitive-motor training on dual-task interference during dual-task walking, dual-task foot pedaling and the corresponding alterations of brain activity.
- Detailed Description
In China, the prevalence of stroke increased by 106.0% (93.7-118.8) between 1990 and 2019, highlighting the persistent and substantial burden of this condition. Post-stroke recovery, particularly the ability to achieve community ambulation, plays a critical role in improving health-related quality of life. Effective community ambulation in daily life requires the ability to dual-task-namely, to perform concurrent tasks requiring attentional resources while maintaining walking function and balance. Emerging evidence suggests that stroke survivors face greater challenges in walking function and dual-task balance compared to their age-matched, able-bodied counterparts. For instance, when tasked with recalling a shopping list while walking, stroke patients exhibit a more pronounced decline in both walking speed and cognitive performance relative to control groups. Given the necessity for stroke survivors to reintegrate into the community, it is imperative to thoroughly investigate this phenomenon of cognitive-motor interference.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 72
- a diagnosis of stroke, stroke onset of more than 6 months,
- aged 50 or more,
- capable of following verbal and visual instructions,
- having a Montreal Cognitive Assessment score ≥ 22,
- able to walk for 10 meters with/without a mobility aid,
- community-dwelling, unilateral stroke
- neurological disorders, gait-precluding pain or comorbidity,
- receiving any formal rehabilitation training,
- contraindications to exercise (e.g., unstable angina),
- contraindications to fNIRS, MRI, and tDCS (e.g., brain skin injury, pacemaker, metal implants in the brain),
- history of seizure or epilepsy,
- color blindness.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Dual-task gait speed Through study completion, an average of 1 year Gait speed under dual-task condition will be recorded
Dual-task cognitive performance Through study completion, an average of 1 year Number of correct responses will be measured during dual-task conditions
- Secondary Outcome Measures
Name Time Method Oxyhemoglobin concentration changes of the brain Through study completion, an average of 1 year Oxyhemoglobin concentration changes will be measured using functional near infra-red spectroscopy during dual-task walking
Dual-task gait performance 1 Through study completion, an average of 1 year Gait cadence will be measured during dual-task walking
Dual-task gait performance 2 Through study completion, an average of 1 year Gait cycle duration will be measured during dual-task walking
Dual-task gait performance 3 Through study completion, an average of 1 year Stride length will be measured during dual-task walking
Dual-task cognitive performance 1 Through study completion, an average of 1 year Correct reaction time under dual-task walking will be recorded
Blood oxygenation level changes of the brain Through study completion, an average of 1 year Blood oxygenation level changes will be measured using Magnetic Resonance Imaging during dual-task foot pedaling
Dual-task stride time Through study completion, an average of 1 year Stride time under dual-task foot pedaling will be recorded
Dual-task cognitive performance 2 Through study completion, an average of 1 year Number of correct responses under dual-task foot pedaling will be recorded
Trial Locations
- Locations (1)
The Hong Kong Polytechnic University
🇭🇰Hong Kong, Hong Kong