Efficacy of Donepezil in the treatment of Major Depressive Disorder
- Conditions
- Major Depressive Disorder.Sever Depressive Episode Without Psychotic Symptoms
- Registration Number
- IRCT2013031011885N2
- Lead Sponsor
- Vice chancellor for research, Mazandaran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 40
Entry: All outpatients with Major Depressive Disorder based on DSM-IV-TR in the age range of 25-55 year old who refer to psychiatric clinic in Zare hospital or Tooba clinic. Exclusion criteria: Catatonia; Acute suicidal idea; Major past medical history; Endocrine diseases; Chronic cardiovascular diseases; Respiratory diseases; Hepatic failure; Renal failure; Active peptic ulcer, Acute infectious diseases; Malignancies; Neurolgic disorders; Axis I psychiatric disorders except of Major depressive disorder; Axis II psychiatric disorders; Family history of bipolar disorder; Concomitant use of psychiatric drugs except for Antidepressants; Outside the age range of 25-55; refuse to participate in the study; Pregnancy, Breastfeeding; Lack of contraception in women of childbearing age.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Memory. Timepoint: Before intervention,End of intervention,3months after ending intervention. Method of measurement: With wechsler memory scale.;Depression. Timepoint: Before intervention,Every month for three months after beginning intervention,3months after ending intervention. Method of measurement: With hamilton depression rating scale.
- Secondary Outcome Measures
Name Time Method Side effects of drugs. Timepoint: 1st,2st.3st month after intervention and three month after ending intervention. Method of measurement: By filling a checklist of drug side effects.