THE MUSCLE POWER STUDY - surgery related muscle loss and muscle strength after complex abdominal surgery for pseudomyxoma peritonei, pancreatic, liver and colorectal cancer

• Conditions: chirurgisch gerelateerd spierverlies; Surgical Related Muscle Loss (SRML); 10027656; 10017998

• Registration Number: NL-OMON46139
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 180

Inclusion Criteria

* Female or male aged at least 18 years;
* The patient must speak the Dutch language;
* The patient understands the purpose of the study and has given written informed consent to participate in the study;
* Diagnosed or the suspicion of a liver tumour (primary cancer or colorectal liver metastases), pancreatic malignancy, bile duct malignancy, colon tumour, rectum tumour, or pseudomyxoma peritonei;
* Scheduled for open major abdominal surgery consisting of the following surgical procedures:
o Cytoreductive surgery combined with hyperthermic intraperitoneal intraoperative chemotherapy) (CRS with HIPEC)
o (Sub)total pelvic exenteration
o Pylorus preserving pancreaticoduodenectomy (PPPD)
o Whipple procedure (classic pancreaticoduodenectomy)
o Subtotal pancreatectomy
o Total pancreatectomy
o Major liver resection, defined as *3 liver segments
* The patient will be operated at the UMCG;
* Presence of a preoperative CT-scan of the abdomen.

Exclusion Criteria

* Scheduled for laparoscopic surgery;
* Minor liver resections, defined as <3 liver segments;

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Our main objective is to measure the amount of clinically relevant SRML<br /><br>(defined as *5% muscle loss within one week measured by the CSA of the<br /><br>different muscles) in cancer patients after major abdominal surgery for<br /><br>pseudomyxoma peritonei, pancreatic, liver and colorectal cancer by using<br /><br>bedside ultrasound and squeeze and force measurements of arms and legs. </p><br>