Evaluation of the effect of scaling and root planing on salivary and serum fetuin-a levels in patients with chronic periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Salivary and serum fetuin-A levels. Probing pocket depth clinical attachment level bleeding on probing
研究概览
简要总结
Periodontitis is a site-specific inflammatory condition of the toothsupporting structures inciting soft tissue destruction and alveolar bone loss.The nexus between different complex cascades generates pro-inflammatory cytokinesthat in turn activate hepatocytic receptors to commence the synthesis ofvarying Acute Phase Proteins (APPs) as part of the non-specific Acute PhaseResponse (APR). APPs are customarily classified as positive and negative basedon their serum concentrations. Hence, they exhibit both pro-inflammatory andanti-inflammatory properties. Various positive and negative APPs have beenstudied in relation to periodontal disease. One such negative APP, fetuin-A hasgarnered colossal recognition in the etio-pathogenesis of several systemicdisorders. It has been recently discovered as an anti-inflammatory marker for periodontaldisease and has coerced researchers to delve into its prospective as adiagnostic and a prognostic marker for periodontal disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Not Applicable
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 25.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •Presence of at least 20 natural teeth Group 1 healthy individuals having no clinical signs of gingival inflammation, no clinical attachment loss and probing pocket depth less than or equal to 3mm Group 2 patients who have been clinically diagnosed with generalized moderate to severe chronic periodontitis, otherwise systemically healthy, based on American Academy of Periodontology 1999 classification found to have clinical attachment loss more than or equal to 3mm in 30% of the sites and probing pocket depth more than or equal to 5mm with at least 6 teeth.
排除标准
- •Patients with history of any systemic disease Pregnancy or lactation Current or former smokers Patients with history of periodontal therapy in the last 6 months Patients with history of antibiotic intake in the last 3 months Patients with history of anti-inflammatory drug therapy in the last 3 months Patients consuming any other medications Patients with any intra oral lesions.
结局指标
主要结局
Salivary and serum fetuin-A levels. Probing pocket depth clinical attachment level bleeding on probing
时间窗: Baseline and 3 months
次要结局
- Gingival index plaque index(3 months)