Childhood Trauma in Schizophrenia: Exploration of Links Between Gene Expression, Cerebral Morphology and Symptomatology. SCHIZO' TRAUMA
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 78
- 试验地点
- 1
- 主要终点
- Quantitative measurement of RNAs
研究概览
简要总结
Childhood trauma is known as a vulnerability factor in schizophrenia. In healthy volunteers, these adversities are linked to a decrease of grey matter of the brain, similar to those observed in schizophrenia.
In a previous study based on Voxel-Based Morphometry (VBM), including 21 schizophrenic patients and 30 healthy volunteers, the investigators shown a negative correlation between emotional neglect (important dimension in childhood trauma) and grey matter decrease. This strong correlation was significantly higher in schizophrenic patients than in healthy volunteers, suggesting a higher genetic predisposition to environmental factors in schizophrenic people.
Currently, interaction between genetic predisposition and environmental stress factors is the major model for understanding in schizophrenia. In order to analyze both effects on human body, particularly on brain, several studies currently focus on the product of genetic expression, the ribonucleic acid (ARN).
The purpose of this study is to provide an explanatory model of links between childhood trauma, candidate gene for schizophrenia expression, cerebral morphology and schizophrenic symptomatology. Using conceptual framework of stress vulnerability, structural equation modeling (SEM) will allow testing causal link between these different variables.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Quantitative measurement of RNAs
时间窗: 5 days
development of an etiopathogenic model characteristic of schizophrenia
Voxel-based morphometry (VBM) for regional gray matter density.
时间窗: 5 days
development of an etiopathogenic model characteristic of schizophrenia
Voxel-based morphometry (VBM) for total gray matter
时间窗: 5 days
development of an etiopathogenic model characteristic of schizophrenia
Childhood Trauma Questionnaire (CTQ) for childhood trauma.
时间窗: 5 days
development of an etiopathogenic model characteristic of schizophrenia Childhood Trauma Questionnaire : to assess five types of childhood trauma : 1. Emotional neglect 2. physical abuse 3. emotional abuse 4. physical neglect 5. sexual abuse Each item being rated in 5 answer choice from 1 to 5 (never, rarely, sometimes, often or very often)
次要结局
- Volumetry of the brain(5 days)
- Correlation of BOLD activity in the cortico-limbic circuit with emotional variables(5 days)
- Correlation of BOLD activity in the cortico-limbic circuit with personality characteristics(5 days)
- Correlation of BOLD activity in the cortico-limbic circuit with history of trauma in childhood(5 days)
- Connectivity in the cortico-limbic circuit(5 days)
- Correlation of BOLD activity in the cortico-limbic circuit in patients with patients with symptomatic variables(5 days)