Childhood Trauma in Schizophrenia: Exploration of Links Between Gene Expression, Cerebral Morphology and Symptomatology
- Conditions
- Schizophrenia
- Interventions
- Device: magnetic resonance imaging (MRI)Procedure: Blood sampleOther: Clinical psychiatric evaluation
- Registration Number
- NCT03355781
- Brief Summary
Childhood trauma is known as a vulnerability factor in schizophrenia. In healthy volunteers, these adversities are linked to a decrease of grey matter of the brain, similar to those observed in schizophrenia.
In a previous study based on Voxel-Based Morphometry (VBM), including 21 schizophrenic patients and 30 healthy volunteers, the investigators shown a negative correlation between emotional neglect (important dimension in childhood trauma) and grey matter decrease. This strong correlation was significantly higher in schizophrenic patients than in healthy volunteers, suggesting a higher genetic predisposition to environmental factors in schizophrenic people.
Currently, interaction between genetic predisposition and environmental stress factors is the major model for understanding in schizophrenia. In order to analyze both effects on human body, particularly on brain, several studies currently focus on the product of genetic expression, the ribonucleic acid (ARN).
The purpose of this study is to provide an explanatory model of links between childhood trauma, candidate gene for schizophrenia expression, cerebral morphology and schizophrenic symptomatology. Using conceptual framework of stress vulnerability, structural equation modeling (SEM) will allow testing causal link between these different variables.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 78
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Healthy volunteers magnetic resonance imaging (MRI) Healthy volunteers will have clinical psychiatric evaluation, brain imaging and blood sample Related volunteers (first degree relative of patient) magnetic resonance imaging (MRI) Related volunteers will have clinical psychiatric evaluation, brain imaging and blood sample Schizophrenic patients Blood sample Patients will have clinical psychiatric evaluation, brain imaging and blood sample Related volunteers (first degree relative of patient) Blood sample Related volunteers will have clinical psychiatric evaluation, brain imaging and blood sample Healthy volunteers Blood sample Healthy volunteers will have clinical psychiatric evaluation, brain imaging and blood sample Schizophrenic patients magnetic resonance imaging (MRI) Patients will have clinical psychiatric evaluation, brain imaging and blood sample Related volunteers (first degree relative of patient) Clinical psychiatric evaluation Related volunteers will have clinical psychiatric evaluation, brain imaging and blood sample Schizophrenic patients Clinical psychiatric evaluation Patients will have clinical psychiatric evaluation, brain imaging and blood sample Healthy volunteers Clinical psychiatric evaluation Healthy volunteers will have clinical psychiatric evaluation, brain imaging and blood sample
- Primary Outcome Measures
Name Time Method Quantitative measurement of RNAs 5 days development of an etiopathogenic model characteristic of schizophrenia
Voxel-based morphometry (VBM) for regional gray matter density. 5 days development of an etiopathogenic model characteristic of schizophrenia
Voxel-based morphometry (VBM) for total gray matter 5 days development of an etiopathogenic model characteristic of schizophrenia
Childhood Trauma Questionnaire (CTQ) for childhood trauma. 5 days development of an etiopathogenic model characteristic of schizophrenia
Childhood Trauma Questionnaire : to assess five types of childhood trauma :
1. Emotional neglect
2. physical abuse
3. emotional abuse
4. physical neglect
5. sexual abuse
Each item being rated in 5 answer choice from 1 to 5 (never, rarely, sometimes, often or very often)
- Secondary Outcome Measures
Name Time Method Volumetry of the brain 5 days Correlation of BOLD activity in the cortico-limbic circuit with emotional variables 5 days emotional variables : ERS scale, ERQ scale, TAS-20 scale, SAS scale, AES-C scale
Correlation of BOLD activity in the cortico-limbic circuit with personality characteristics 5 days personality characteristics : EPQ-R scale, SPQ scale
Correlation of BOLD activity in the cortico-limbic circuit with history of trauma in childhood 5 days history of trauma in childhood : CTQ scale
Connectivity in the cortico-limbic circuit 5 days Correlation of BOLD activity in the cortico-limbic circuit in patients with patients with symptomatic variables 5 days symptomatic variables : PANSS scale
Trial Locations
- Locations (1)
CHU de Saint Etienne
🇫🇷Saint-Étienne, France