Comparison of local versus systemic tranexamic acid in total knee replacement

Completed

• Conditions: Primary Osteoarthritis Knee

• Registration Number: CTRI/2017/07/009076
• Lead Sponsor: SUNSHINE HOSPITALS

Brief Summary

This study is intended to test for non-inferiority between intraarticular and intravenous routes for administration of tranexamic acid for control of perioperative blood loss in total knee replacement surgeries in terms of efficacy and safety

Detailed Description

Not available

Study Timeline

• Study Completion: 2017-04-28
• Last Update Posted: 2017-07-17
• Study Start: 2017-09-01

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 113

Inclusion Criteria

• All patients undergoing total knee arthroplasty for primary arthroplasty knee 2.Patients who are willing to participate in the study.
• 3.Patient without exclusion criteria.

Exclusion Criteria

• 1.Allergy to the TXA 2.H/O Coagulopathy,abnormal PT or APTT 3.Past H/O Thromboembolic event 4.Treatment with Aspirin or NSAIDS in the last week 5.plasma creatinine > 115 micro moles /litre for males And >100 micro moles/litre in females.
• 6.Acute infection[eg;leukocytosis or fever] 7.Malignancy 8.MI in preceding 12 months,unstable angina 9.Patient who were given plasma in perioperative period.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative Hemoglobin drop	Assessed at 3 days of surgery

Secondary Outcome Measures

Name	Time	Method
Perioperative blood loss, need for post operative	blood transfusion, impairment of renal function,

Trial Locations

Locations (1)

SUNSHINE HOSPITALS; 🇮🇳 Hyderabad, ANDHRA PRADESH, India

SUNSHINE HOSPITALS

🇮🇳Hyderabad, ANDHRA PRADESH, India

JEFFERSON GEORGE

Principal investigator

09447777890

jeffgeorge007@gmail.com