Effect of Long-term Transcranial Direct Current Stimulation (tDCS) on Appetite Control Related Brain Regions
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obesity
- Sponsor
- Chungbuk National University
- Enrollment
- 27
- Locations
- 1
- Primary Endpoint
- Regional brain activity measured by blood-oxygen-level dependent (BOLD) signal of functional MRI
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of this study is to investigate the long-term effect of Transcranial Direct Current Stimulation (tDCS) on appetite control related brain regions.
Detailed Description
Transcranial direct current stimulation (tDCS) is emerging tool for brain modulation in a variety of clinical conditions. In addition, recent neuroimaging studies suggest that modifying the activity of brain circuits involved in eating behavior could provide therapeutic benefits in obesity. The investigators aim to assess whether long-term modulation of the dorsolateral prefrontal cortex (DLFPC) using tDCS, modifies behavioral response and brain activity while watching visually presented food cues and taste cues in obese subjects. Subjects will be randomly divided into sham and real tDCS arms. Subjects will receive sham or real tDCS ten times. Subjects will be investigated before and after sham or real tDCS interventions. Subjects will perform functional MRI experiments with visual and taste food cues. Questionnaire with behavior measures, body compositions, blood tests will be performed.
Investigators
Hyung Jin Choi
Clinical Assistant Professor
Chungbuk National University
Eligibility Criteria
Inclusion Criteria
- •BMI \> 26 kg/m2
Exclusion Criteria
- •History of brain trauma, epilepsy, or other neurological problems
Outcomes
Primary Outcomes
Regional brain activity measured by blood-oxygen-level dependent (BOLD) signal of functional MRI
Time Frame: Day 14 (After ten interventions)
3T MR scanner with Echo Planar Imaging(EPI) capability(Magnetom, Siemens Medical System)
Secondary Outcomes
- Behavior outcomes on the visual analog scale(Day 14 (After ten interventions))