Observation study of breathing in diaphragmatic dysfunction patients during weaning by Electrical Impedance Tomography
- Conditions
- Diseases of th respiratory system
- Registration Number
- KCT0003567
- Lead Sponsor
- Asan Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 100
Patients admittedin the ICU of Asan Medical Center, a university-affiliated, tertiary referral center in
Seoul, Korea, over 18 years adults who required mechanical ventilation for 48 hrs is ready to wean and T-piece trial.
1) Partial pressure of arterial oxygen (PaO2) =60 on FiO2 0.5
2) positive end-expiratory Pressure level =6 cmH2O
3) Glasgow Coma Scale scre>13 or Richmond Agitation-Sedation Scale -1 ~ 1
4) Body temperature <38 °C
5) Hct >21% or Hb>7.0g/dl
6) Low dosages of vasopressors or sedatives8 respiratory,
Patients admittedin the ICU of Asan Medical Center, a university-affiliated, tertiary referral center in
Seoul, Korea, over 18 years adults who required mechanical ventilation for 48 hrs is ready to wean and T-piece trial.
1) age < 18
2) Pregant
3) Previous history of diaphragm palsy, spine injury and Neuromuscular disease(Guilin Barre disease, Myasthenia gravis etc)
4) Pneumothorax or pneumomediastinitis
5) Large amount pleural effusion or If there is a lung lesion adjacent to the diaphragm
6) Hypothyroidism
7) Uncontrolled arrhythmia or seizure
8) Prolonged Mechanical ventilation over 30days
9) Neuromuscular blocker stopped within 48hours
10) Thoracostomy states
11) Contraindication of EIT: Pacemaker, ACD insertion states, Skin lesion on thorax, over BMI 35
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Variation of Regional ventilation distribution during Spontaneous Breathing trial and Extubation; Electrical Impedance tomography index at 20minutes after Spontaneous Breathing trial, and extubation
- Secondary Outcome Measures
Name Time Method Success rate of SBT, Success rate of Weaning