Augmented Renal Clearance in The Intensive Care Unit - A Multicenter Study

Not Applicable

Completed

• Conditions: Critical Illness; Infection - Studies of infection and infectious agents; Inflammatory and Immune System - Other inflammatory or immune system disorders; Injuries and Accidents - Other injuries and accidents

• Registration Number: ACTRN12610000116022
• Lead Sponsor: Royal Brisbane and Womens Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-02-03
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 281

Inclusion Criteria

Any patient requiring admission to the ICU with:
a) Expected length of stay (LOS) > 24hours
b) Normal renal function (admission serum creatinine < 120 umol/L)

Exclusion Criteria

1)Absence of invasive haemodynamic monitoring as a part of routine management
2) Absence of an indwelling urinary catheter (IDC) as a part of routine management
3) Evidence of renal impairment
4) 'At Risk' of acute kidney injury (AKI) (> 1.5 fold increase in Serum Creatinine from baseline or urine output (UO) < 0.5ml/kg/hr for > 6hrs prior to enrolment
5) Age < 18years
6) Pregnancy
7) Lack of informed consent
8) Rhabdomyolysis is suspected clinically or serum creatinine kinase > 5000
9) Clinician considers the patient is unsuitable for enrolment

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome is the incidence of augmented renal clearance (ARC) in patients admitted to the ICU. Daily 8-hour creatinine clearance measures will be used to identify this, with figures > 160ml/min/1.73m2 and > 150ml/min/1.73m2 in young men and women respectively indicating ARC. <br><br>These measures are obtained by collecting the patients urine (by means of an indwelling urinary catheter) over an 8-hour period. A blood sample is drawn during this period, and the creatinine concentration is then estimated in both urine and blood.<br><br>The creatinine clearance is then calculated as: urinary creatinine concentration x urinary volume / plasma creatinine concentration, giving a figure in ml/min. This is then adjusted using the patients body surface area to a standard figure of 1.73m2 (to allow comparison between patients).[Daily until discharge from the ICU]