NCT07041372Enrolling By Invitation不适用
Cerebral Atherosclerosis Research With Positron Emission Tomography
适应症
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 310
- 试验地点
- 1
- 主要终点
- Vascular events
研究概览
简要总结
The goal of this clinical trial is to learn if the application of fluorodeoxyglucose positron emission tomography can predict prognosis of stroke patients. The main questions it aims to answer are:
- Does FDG PET can predict future vascular events such as stroke recurrence, myocardial infarction or vascular death among stroke survivors?
- Does FDG PET can predict other important events such as fracture, dementia, bleeding, cancer and overall death among stroke survivors? Researchers will compare the FDG uptake in major organs - such as the amygdala, vertebrae, spleen, liver, internal carotid artery, visceral fat, and psoas muscle - between patients with and without the event of interest to determine whether FDG PET can predict the overall prognosis of stroke patients.
Participants will:
- Undergo whole-body FDG PET once their neurological status has stabilized after stroke.
- Complete questionnaires assessing stress and anxiety (PHQ-9 and PSS-10) on the same day.
- Maintain regular clinic visits for up to 24 months following the index stroke
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •acute ischemic stroke patients who admitted within seven days after symptom onset
排除标准
- •Patients with unstable vital signs or neurological symptoms
- •Patients with estimated glomerular filtration rate less than 30ml/min
- •Patients with uncontrolled diabetes requiring persistent insulin injection
- •During pregnancy or while breastfeeding
- •Patients with impaired consent capacity
- •Patients with diagnosed/treatment for dementia
- •Patients undergoing treatment for malignant tumors or serious autoimmune diseases
结局指标
主要结局
Vascular events
时间窗: up to 24 months after index stroke
Stroke, myocardial infarction, vascular death
次要结局
- overall vascular events(up to 24 months after index stroke)
研究者
Jeong-Min Kim
Professor
Seoul National University Hospital
研究点 (1)
Loading locations...
相似试验
已完成
1 期
Evaluate the Utility of 18FDG-PET as a Tool to Quantify Atherosclerotic Plaque (MK-0000-081 AM3)(COMPLETED)Atherosclerotic Vascular DiseaseNCT00703261Merck Sharp & Dohme LLC83
撤回
1 期
A FDG-PET Study of AGN-242071 Added to Standard-of-Care (Donepezil ± Memantine) for the Treatment of Participants With Mild to Moderate Alzheimer's DiseaseAlzheimer's DiseaseNCT03316898Allergan
已完成
2 期
PET/CT and WB MRI for Staging and Response in CRPC Patients Receiving EnzalutamideProstate Cancer MetastaticNCT02814968The European Uro-Oncology Group66
终止
不适用
FDG-PET as an Imaging Modality to Diagnose and Risk Stratify Subclinical, Imaging Negative Ici-MyocarditisSubclinical Immune Checkpoint Inhibitor-Induced MyocarditisICI-MyocarditisSolid Malignant TumorHematologic MalignancySubclinical MyocarditisSubclinical ICI-myocarditisMyocarditisNCT06566209Mayo Clinic2
终止
1 期
Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain TumorsAdult Anaplastic AstrocytomaAdult Anaplastic EpendymomaAdult Anaplastic OligodendrogliomaAdult Brain Stem GliomaAdult Central Nervous System Germ Cell TumorAdult Choroid Plexus TumorAdult CraniopharyngiomaAdult Diffuse AstrocytomaAdult EpendymoblastomaAdult EpendymomaAdult Giant Cell GlioblastomaAdult GlioblastomaAdult GliosarcomaAdult Grade I MeningiomaAdult Grade II MeningiomaAdult Grade III MeningiomaAdult MedulloblastomaAdult Meningeal HemangiopericytomaAdult Mixed GliomaAdult Myxopapillary EpendymomaAdult OligodendrogliomaAdult Pilocytic AstrocytomaAdult PineoblastomaAdult PineocytomaAdult SubependymomaAdult Supratentorial Primitive Neuroectodermal Tumor (PNET)Meningeal MelanocytomaNCT00110032National Cancer Institute (NCI)46