Does Vitamin D improve markers of vascular health in type 2 diabetes?

Completed

• Conditions: Type 2 diabetes mellitus; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN46424296
• Lead Sponsor: niversity of Dundee (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-09-12
• Last Update Posted: 2 October 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Age =18 years
2. Vitamin D level <50 nmol/l

Exclusion Criteria

1. Serum creatinine >200 µmol/l
2. Liver function tests >3 x upper limit of normal
3. Corrected calcium >2.55 mmol/l or <2.15 mmol/l
4. Metastatic malignancy
5. Unable to give informed consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Current primary outcome measures as of 29/08/2017:<br>Flow-mediated dilatation of the brachial artery in response to reactive hyperaemia, measured by ultrasound at baseline and 8 weeks<br><br>Previous primary outcome measures:<br>Change in flow mediated dilatation of the brachial artery

Secondary Outcome Measures

Name	Time	Method
Current secondary outcome measures as of 29/08/2017:<br>1. 25-hydroxyvitamin D, serum calcium, serum phosphate, parathyroid hormone levels, measured by blood tests at baseline and 8 weeks<br>2. Glycosylated haemoglobin, insulin sensitivity using HOMA index, measured by blood tests at baseline and 8 weeks<br>3. Office blood pressure, measured by blood pressure cuff at baseline and 8 weeks<br>4. Renin and angiotensin levels, measured by blood tests at baseline and 8 weeks<br><br>Previous secondary outcome measures:<br>Pulse wave velocity, homeostasis model assessment (HOMA) index, renin, angiotensin, Vitamin D, parathyroid hormone (PTH)