Effect of Vitamin D supplementation on vascular functions in type 2 diabetic patients with vitamin D deficiency.
Not Applicable
- Conditions
- Health Condition 1: null- Type 2 dibetes mellitus patients
- Registration Number
- CTRI/2016/03/006698
- Lead Sponsor
- JIPMER
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 66
Inclusion Criteria
Patients diagnosed with type 2 diabetes mellitus for past 10 years or less and on stable treatment for past 3 months, and taking metformin or sulphonylurea or both.
Exclusion Criteria
1)Liver dysfunction (AST,ALT > 1.5 times the upper limit of normal)
2)Renal dysfunction (Serum creatinine, blood urea > 1.5 times the upper limit of normal)
3)Patient with concurrent illnesses other than hypertension
4)Patients taking enzyme inducers or inhibitors
5)Patients already taking vitamin D supplements
6)Pregnant and lactating woman
7)Severe uncontrolled hypertension ( >160/90 mm Hg)
8)Smokers
9)Patients who had participated in other trials within last 3 months
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in carotid femoral pulse wave velocityTimepoint: Change in carotid femoral pulse wave velocity after 8 weeks of vitamin D supplementation.
- Secondary Outcome Measures
Name Time Method Change in brachial artery pulse wave velocity, arterial stiffness index, serum malondialdehyde levels and total anti oxidant status .Timepoint: After 8 weeks of vitamin d supplementation