EUCTR2013-001143-31-DK进行中（未招募）1 期
TARGETTargeting the small airways in asthma”Does fine particle ICS improve peripheral airway inflammation and function in patients with insufficient response to large particle ICS? - TARGET
Bispebjerg University Hospital0 个研究点目标入组 40 人开始时间: 2013年6月28日最近更新:
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •Asthma diagnosed by at least one objective test within last 12 months:
- •?positive bronchial provocation test (mannitol or methacholine),
- •?reversibility to beta-2 agonist (> 12 %, and > 250 mL) or
- •?PEF variation (>20%)
- •1.Treated with daily ICS +/- LABA for at least 3 months
- •2.Partly controlled or uncontrolled asthma according to GINA guidelines definitions, and
- •3.Positive mannitol bronchial provocation test (PD15< 450 mg) at screening and after 4 week run-in.
- •4.Signs of eosinophilic airway inflammation (FeNO > 25 ppb)
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 40
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
排除标准
- •1.Other lung diseases
- •2.Active smoking past 12 months
- •3.Ex-smokers (< 12 months: > 10 pack years)
- •4.Pregnancy or lactation
- •5.Respiratory infection (past 6 weeks)
研究者
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