跳至主要内容
临床试验/CTRI/2024/06/068941
CTRI/2024/06/068941尚未招募4 期

A randomized comparative clinical study to evaluate the efficacy of Mashaadi Kashaya Basti over Dashamoola Ksheera Basti in Pakshaghata with special reference to Ischemic Stroke

Dr Shreedevi B Huded1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2024年6月28日最近更新:

试验速览

阶段
4 期
状态
尚未招募
发起方
入组人数
40
试验地点
1
主要终点
Improvement in cardinal feature of Pakshaghata Chesta Nivrutti in Dakshina and Vama Parshwa Ardhakayakarmahani Vaksang Ruja Suptata in hasta and pada

研究概览

简要总结

Vata is the only Dosha which governs all the other entities of the body like Pitta, Kapha, Dhatu etc. Diseases caused by Vata in its vitiated condition are called Vatavyadhi.Soa proper understanding of the concept of Vata is required in order to keep all the body functions in equilibrium.Although Vata is said to be dominated during the old age only,but in present timedue to fast and busy life,stress,prolonged sitting posture in working place dietaryhabits, working late night, improper sleep etc. Vata is seen to be aggravated even in the young individuals.

Pakshaghata is the major disabling disease manifests as a Paralysisof one side of the body due to the vitiation of Vata Dosha.Pakshaghata is Vata Vikaraof rapidly or gradual developing clinical science of focal or global disturbance of limbs movements and sensation and symmetrical loss of body functions. It manifests due to disturbance in the Vata Vaha Samsthana that is Mantishka, leading to impairment of function of Vata that is Chesthhani either in left or right of the body. Pakshaghata is one among the 80 Vata Vikarasa and being one among the Mahaghadas.

According to WHO, Stroke is focal and global disturbance of cerebral blood circulation which is either ischemic or Haemorrhagic with symptoms lasting 24 hours or longer are leading death. Stroke is leading cause of disability worldwide and 3rd leading cause of death and it not only changesphysical, mental, economical status of patient,but also of their family. The estimated prevalence rate stroke range 48-262/100000 in rural and 334-424/100000 Urban,incidence rate 119-145/100000 based on recent population. About 87% of all 1st ever in life time stroke are ischemic, 13% due to primary intra cerebral haemorrhage.

General approach of Stroke management including physiotherapy is part of rehabilitation following Stroke, it can help to restore the loss of movement and strength. But it has more limitation and restriction when compared to Ayurveda. In the management of Pakshaghatait is very difficult to make complete cure hence many patients retain permanent disability,spasticity and rigidity as a permanent damage. Toovercome such condition an attempt is made to evaluate the efficacy of Basti Karma.

The Basti is the treatment which is considered as best therapy to control Vata and to prevent Vimargamanaof Vata. Basti will dose the SarvadoshaShamana, Vatanulomanaand Srothoshodhana.Acharya Charaka highlighted that “BASTI VATA HARANAM SHRESTA”and it dose the Shodhanaof Dosha from “Pada to Mastishkya”, hence conclusively Basti is the Ardha Chikista.

In the present study DashamoolaKsheera Bastiis planned. Dashamoola possesses Vata and Kaphahara properties, it is included in ShothaharaMahakashaya by Acharya Charaka.Dashamoola having Madhura rasa, Laghu Guna and Madhura Vipaka helps to pacify vitiated Vata, Kashaya Rasa and Ushna Veerya does Amapachana & cleanses the Srotasa. Collectively the actions of Dashamoola are Vatahara, Parshvashulahara, Shothahar, Balya, Amapachaka.

Ksheer is having Madhura Rasa, Snigdha Guna, Madhura Vipaka and it is Jeevaniya, Balya, Anulomaka in nature.

DashamoolaKsheera Basti is widely practiced. Its compostionof the drug influences Vatanulomaka, Balya, Shothahara, Shoolahara, Amapachaka.

In the present study MashadiKashaya ingredients are Masha Beeja,Aatmagupta Beeja, Erandamoola, Balamoola, Saindhava Lavana andHinguhave the properties like Vatagna, Vedanastapana,Santarpana,Poustika,Balya,Bhrumhana,Shoolagna,Shothagna, Angamardaprashamana,Snehana,Tridoshashamaka,Vatashleshmahara,Vatanulomaka which is expected to manage the Pakshaghata effectively.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
None

入排标准

年龄范围
30.00 Year(s) 至 70.00 Year(s)(—)
性别
All

入选标准

  • Subjects with following signs and symptoms Chesta Nivrutti in Dakshina and Vama Parshwa Ardhakayakarmahani Vaksanga Ruja Suptata in hasta and pada Subjects suffering from Ischemic Stroke without any severe complications Subjects of either gender are included Subjects of age groups between 30-70 years are included Subjects fit for Basti Karma.

排除标准

  • Subjects having dysphagia Incontinence of bowel and bladder Subjects who are disoriented and unconscious Uncontrolled Diabetes Mellitus Hypertension Intracranial infections like meningitisen cephalitis etc Post traumatic stroke Haemorrhagic stroke Space occupying lesions of brain such as tumours Congenital defects such as diffuse sclerosis cerebral agenesis etc & other major illness Subjects who are suffering with Chronic KidneyDiseases Acute Kidney Diseases Congestive Cardiac Failure& Ischemic Heart Disease.

结局指标

主要结局

Improvement in cardinal feature of Pakshaghata Chesta Nivrutti in Dakshina and Vama Parshwa Ardhakayakarmahani Vaksang Ruja Suptata in hasta and pada

时间窗: after 24 days

次要结局

  • Assessment of improvement through stroke scale of national health institute of neurological disorders & stroke NIH & NINDS & modified Rankins Disability Scale(after 24 days)

研究者

发起方
Dr Shreedevi B Huded
申办方类型
Research institution and hospital
责任方
Principal Investigator
主要研究者

Dr Shreedevi B Huded

D G M Ayurvedic Medical College Gadag Gadag

研究点 (1)

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