Prevention of Frailty in Breast Cancer Survivors: A Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 27
- 试验地点
- 2
- 主要终点
- Reproducibility of muscle activation by subcutaneous fat mass measures.
研究概览
简要总结
This trial studies how well weight bearing exercise works in preventing frailty in stage I-IIIA breast cancer survivors. Weight bearing exercise, including muscle-strengthening, aerobic, flexibility, and balance exercises, can decrease fat and increase muscle, which may lead to reduced frailty.
详细描述
PRIMARY OBJECTIVES:
I. Demonstrate reproducibility of forearm muscle activation and subcutaneous fat measures in a healthy convenience sample/population (N= 10).
II. Demonstrate that measures of muscle activation and signal attenuation by subcutaneous fat mass can be conducted in a systematic and reproducible fashion in breast cancer survivors prior to and following weight bearing exercise training.
III. In a cross sectional analysis, describe the level of lean muscle mass, muscle activation, strength, insulin resistance, inflammatory cytokines and growth factors, and inter-individual variability in breast cancer survivors prior to training.
IV. Describe the level of lean muscle mass, muscle activation, strength, insulin resistance, inflammatory cytokines (such as IL-6, CRP and others), and growth factors (such as myostatin, IGF-1, IGFBP-3 and others) in breast cancer survivors following weight bearing exercise training.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 37 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Post-menopausal (12 months without menstrual period: naturally, surgically, by hormone suppression).
- •History of early stage breast cancer (stage I, II, IIIa).
- •At least 6 months from chemotherapy.
- •May be receiving hormonal therapy during the study.
- •Currently disease-free, including a negative mammogram within 1 year.
- •Body mass index (BMI) between 25 and 40kg/m^
- •In general good health with no acute or chronic disease that could worsen with weight bearing exercise.
- •Not currently on a prescribed diet nor reporting weight loss of > 10 pounds (lbs) in previous 3 months.
- •Not currently participating in physical activity (PA) independently or a structured program (performing < 120 min of low-intensity, low-impact exercise per week; and no weightlifting or similar physical activity).
- •Ability to participate in physical activity, not limited by severe disability (e.g., severe arthritic conditions); chronic back pain, or history or presence of diseases for which increased physical activity would not be advised.
- •No severe chronic disease, other than breast cancer (e.g., human immunodeficiency virus/acquired immunodeficiency syndrome [HIV/AIDS], kidney failure, liver failure, chronic obstructive pulmonary disease, congestive heart failure, Alzheimer?s, unstable angina, uncontrolled asthma, uncontrolled diabetes, uncontrolled hypertension).
- •No implanted cardiac pacemaker, cardiac defibrillator, or other implanted electronic medical equipment.
- •No history of drug or alcohol abuse.
- •Able to remain in a lying or sitting position for an extended period (> 30 minutes).
- •No history or presence of a significant psychiatric disorder or any other condition that would interfere with participation in the trial.
- •Medical clearance by treating physician.
- •Willing to discontinue nonsteroidal antiinflammatory drug (NSAID) use, except Tylenol and baby aspirin (80mg), 1 week prior to blood draws.
- •Willing to maintain body weight during the study.
- •Can be reached by telephone.
- •Willing to complete consent process and sign informed consent form.
排除标准
- 未提供
研究组 & 干预措施
Prevention (weight bearing exercise program)
Participants undergo a weight bearing exercise program in a group 2 days a week and at home 5 days a week for 8 weeks.
干预措施: Exercise Intervention (Behavioral)
结局指标
主要结局
Reproducibility of muscle activation by subcutaneous fat mass measures.
时间窗: Up to 9 years
Demonstrate reproducibility of forearm muscle activation and subcutaneous fat measures in a healthy convenience sample/population (N= 10). Standard anthropometric measurements (height, weight, waist, hip and arm circumferences) will be taken at baseline and 8weeks. A total body dual energy X-ray absorptiometry (DXA) scan, with an effective radiation dose of about 0.01 mSv, which is about the same as background radiation in one day according to the American College of Radiology (http://www.radiologyinfo.org/en/safety/index.cfm?pg=sfty_xray#3), will be used to determine fat mass and fat free mass at these same time-points. Skeletal muscle mass will be determined by using both appendicular lean mass/height2 method and the residuals model from the Health ABC Study.
Amount of lean muscle as determined by using both appendicular lean mass/height2 method and the residuals model from the Health ABC Study.
时间窗: 8 weeks
Skeletal muscle mass will be determined by using both appendicular lean mass/height2 method and the residuals model from the Health ABC Study.
Reproducibility of signal attenuation using electromyography (EMG)
时间窗: Up two weeks
Maximal isometric muscle activation of the forearm flexors by electromyography (EMG) will be assessed by a pair of surface electrodes (plus 1 ground), to minimize participant burden. EMG data will be amplified and recorded by BIOPAC Systems MP35, 4-channel acquisition system and BSL Pro 3.7 software (BIOPAC Systems, Inc. Goleta, CA), during each of 4, 2-second, repetitions on the 100kg hand grip isometric dynamometer, integrated into the BIOPAC system. Sampling rate and acquisition length will be standardized. The I-beam tool will select the initiation of and conclusion of each contraction. Contraction 1 for each participant will be used for exercise familiarization and dropped, contractions 2-4 will be averaged to for maximal isometric muscle activation (mV). Normally, the non-dominant arm would be evaluated, but since this particular population may have functional limitations on either or both sides due to surgery (i.e. lymphectomy or mastectomy), both arms will be measured.
Level of strength as measured by 8-12 repetition maximum (RM) and by hand grip dynamometer.
时间窗: Up to 8 weeks
A standard submaximal test of strength, 8-12 repetition maximum (RM) will used to evaluate strength and maintain loads in the lower body, which has been safe and effective in previous studies. Strength by hand grip dynamometer will also be measured at baseline and 8wks post-training.
次要结局
未报告次要终点