The Relationship Between Autobiographical Memory and Motivation

Not Applicable

• Conditions: Psychosis
• Interventions: Behavioral: Guided Autobiographical Memory Recall

• Registration Number: NCT03677635
• Lead Sponsor: King's College London

Brief Summary

People with a diagnosis of psychosis often experience low motivation and pleasure when thinking about doing future activities. This leads, quite understandably, to doing fewer activities they used to enjoy and not taking up opportunities to do new activities. One model suggests that this may be partly due to difficulties using memories of previous events to help boost motivation and anticipation before a future activity. Research shows that people with psychosis may recall previous events in less detail. These memories therefore may not be as helpful as they could be for motivation. This study will investigate this by asking people with experience of psychosis and low motivation who are seen by a care team in South London and Maudsley NHS Trust to attend two research sessions. In the first session they will be asked to recall memories of events from their lives and the researcher will assess how detailed they are and how much they refer to the past and future. Alongside this task people will also be asked to complete measures of symptoms such as low pleasure and motivation as well as a measure of depression. These will be used to find out if the detail and specificity of the memories are related to these symptoms in people with psychosis. The second half of the study will then investigate whether additional prompts to support positive memory retrieval can increase the specificity of this and subsequently improve mood, motivation and self-belief. Participants will be randomised to one of two groups. The clinical group will be guided through their memory recall using prompts and a control group will be asked to recall positive memories without prompts. If we show that supporting memory recall is beneficial then memories for past events may be an important target for future therapies.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-02-10
• Study Start: 2017-05-18
• Primary Completion: 2018-03-31
• Status Verified: 2018-09
• Study First Submitted QC: 2018-09-17
• Last Update Submitted: 2018-09-17
• Study First Posted: 2018-09-19
• Last Update Posted: 2018-09-19
• Study Completion: 2019-01-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• A diagnosis of non-affective psychosis (as determined by medical records).
• Above 18yrs old.
• A score of at least 18 on the Clinical Assessment Interview for Negative Symptoms.
• A sufficient command of the English language to engage with the research materials

Exclusion Criteria

• Lack of capacity to provide informed consent.
• Primary diagnosis of intellectual disability, head injury, substance misuse or known organic cause of psychosis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intervention	Guided Autobiographical Memory Recall	Guided autobiographical memory recall to enhance specificity and links to the future.

Primary Outcome Measures

Name	Time	Method
Change in Motivation	Immediately before and after completing the intervention (20mins apart)	A change in ratings on a visual analogue scale assessing motivation to repeat the same activity recalled in the future.The scale is rated from 0-100 and a higher score indicated better outcome. This scale will be reported separately and not combined with others.

Secondary Outcome Measures

Name	Time	Method
Change in Self-efficacy	Immediately before and after completing the intervention (20mins apart)	A change in ratings on a visual analogue scale assessing how able the participant feels to engage in that activity if repeated.The scale is rated from 0-100 and a higher score indicated better outcome. This scale will be reported separately and not combined with others.
Change in Anticipatory Pleasure	Immediately before and after completing the intervention (20mins apart)	A change in ratings on a visual analogue scale assessing how pleasant that activity is anticipated to be if repeated.The scale is rated from 0-100 and a higher score indicated better outcome. This scale will be reported separately and not combined with others.

Trial Locations

Locations (2)

South London and Maudsley NHS Trust; 🇬🇧 London, United Kingdom

Institute of Psychiatry, Psychology & Neuroscience, KCL; 🇬🇧 London, United Kingdom