Impact of Coenzyme Q10 and Selenium on Seminal Fluid and Semen Antioxidant Status

Not Applicable

Completed

• Conditions: Male Infertility
• Interventions: Dietary Supplement: Selenium; Dietary Supplement: Coenzyme Q10

• Registration Number: NCT03834831
• Lead Sponsor: University of Sumer

Brief Summary

The study was conducted to assess the impact of coenzyme Q10 and selenium on seminal fluid parameters and antioxidant status in infertile men.

Detailed Description

The aim of this study was to assess the impact of coenzyme Q10 and selenium on seminal fluid parameters and antioxidant status in infertile men with idiopathic oligoasthenoteratospermia.

Study Timeline

• Study Start: 2018-06-01
• Primary Completion: 2018-10-31
• Study Completion: 2019-01-10
• Study First Submitted: 2019-02-06
• Study First Submitted QC: 2019-02-06
• Study First Posted: 2019-02-08
• Status Verified: 2019-03
• Last Update Submitted: 2019-03-12
• Last Update Posted: 2019-03-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 70

Inclusion Criteria

• History of infertility of at least 12 months despite regular unprotected intercourse.
• Oligoasthenoteratospermia was diagnosed by semen analysis showing abnormal sperm concentration (<15 million/ml), progressive motility (<32%), total motility (<40%) and morphology (<30% WHO criteria) as defined by WHO manual for semen analysis 2010

Exclusion Criteria

• Azoospermia,
• Varicocele,
• Genital tract infection,
• Cryptorchidism,
• Testicular trauma or scrotal surgery,
• Endocrine disorder,
• Systemic illness,
• Smoking
• The presence of female factor

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Selenium	Selenium	Selenium mcg/day for 3 months
Coenzyme Q10	Coenzyme Q10	Coenzyme Q10 200mg/day for 3 months

Primary Outcome Measures

Name	Time	Method
Sperm concentration in semen (WHO 2010 guidelines)	3 months	Sperm concentration in million/ml
Semen volume (WHO 2010 guidelines)	3 months	Semen volume in ml
Sperm morphology in semen (WHO 2010 guidelines)	3 months	Normal sperm morphology (%)
Seminal plasma TAC (Colorimetric assays)	3 months	Seminal plasma total antioxidant capacity in mmol/ml
Seminal plasma CAT (Colorimetric assays)	3 months	Seminal plasma catalase in U/ml
Sperm motility in semen (WHO 2010 guidelines)	3 months	Sperm motility (%)
Seminal plasma SOD (Colorimetric assays)	3 months	Superoxide dismutase in U/ml

Trial Locations

Locations (1)

Fertility Unit, Babyl; 🇮🇶 Hilla, Iraq