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Clinical Trials/TCTR20160314002
TCTR20160314002
Recruiting
Phase 1

A pilot, comparison study of the treatment in acute attack of neuromyelitisoptica: Intravenous methylprednisolone versus plasma exchange alone

none0 sites10 target enrollmentMarch 14, 2016
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ConditionsMotor power grade ≤ 2 Medical research council for first attackAt least 2&#45point worsening in 1 of the pyramidal of functional system score (FSS) compared to last visitAt least 1&#45point worseningneuromyelitis optica spectrum disorderNMOSDplasma exchangeintravenous methylprednisolone

Overview

Phase
Phase 1
Intervention
Not specified
Conditions
Motor power grade ≤ 2 Medical research council for first attackAt least 2&#45
Sponsor
none
Enrollment
10
Status
Recruiting
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
March 14, 2016
End Date
January 1, 2017
Last Updated
last year
Study Type
Interventional
Sex
All

Investigators

Sponsor
none

Eligibility Criteria

Inclusion Criteria

  • •Diagnosis of neuromyelitis optica/neruomyelitis optica spectrum disorder
  • •Admit at siriraj hospital during 2016\-2017
  • •Diagnosis of acute severe attack of NMO within 30 days
  • •Severe attack was defined at least one of the following
  • •Motor power grade ≤ 2 Medical research council for first attack
  • •At least 2\-point worsening in 1 of the pyramidal of functional system score (FSS) compared to last visit
  • •At least 1\-point worsening in EDSS score compared to last visit if previous EDSS score is 5\.5 or more
  • •Visual acuity ≤ 20/200 one eye
  • •Glascow coma scale \< 6
  • •Hemodynamic instability or respiratory failure

Exclusion Criteria

  • •Previous treatment with intravenous steroid
  • •Time to next relapse shorter than 90 days
  • •Serious / uncontrolled infection
  • •Hemodynamic unstable

Outcomes

Primary Outcomes

Not specified

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