Ketamine Associated With Morphine PCA After Total Hip Arthroplasty
Not Applicable
Completed
- Conditions
- Arthroplasty, Replacement, Hip
- Interventions
- Registration Number
- NCT00797264
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Brief Summary
Ketamine (an analgesic drug often associated with morphine in the treatment of Opioid Induced Hyperalgesia) is often mixed in Morphine PCA syringe. We make the hypothesis that ketamine administrated separately via a continuous infusion, could induced a better analgesic effect.
We will perform a randomised double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion.
- Detailed Description
Double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 18
Inclusion Criteria
- total hip arthroplasty
Exclusion Criteria
- pre operative opioid administration
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description A Ketamine-Morphine Ketamine pre and per operative, and morphine postoperative C Postoperative PCA of Ketamine and morphine Ketamine and morphine postoperative B Morphine NaCl pre and per operative, and morphine postoperative
- Primary Outcome Measures
Name Time Method Morphine consumption in PACU and in hospitalisation room at 24 and 48 hours
- Secondary Outcome Measures
Name Time Method Postoperative Visual Analogic Score of pain in Recovery Room, at 24 and 48 hours, in the ward Postoperative Measure of mechanical hyperalgesia by Von Frey filament device 24 and 48 hours in the ward Postoperative measure Ketamine and Nor-Ketamine blood levels at 24 and 48 hours in the ward
Trial Locations
- Locations (1)
Service d'anesthesie-reanimation - Hôpital Bicêtre
🇫🇷Le Kremlin Bicêtre, France