Kidney injury after major surgery

Not Applicable

Completed

• Conditions: Acute kidney injury; Urological and Genital Diseases

• Registration Number: ISRCTN95031194
• Lead Sponsor: Queen Mary University of London

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-12-18
• Study Completion: 2018-11-01
• Last Update Posted: 10 December 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 1500

Inclusion Criteria

1. Aged 45 years or over
2. Elective major non-cardiac surgery
3. Anticipated hospital stay of more than 48 hours
4. Prospective written informed patient consent

Exclusion Criteria

1. Pregnancy
2. No fixed address or home location outside of 30km of study centre
3. Purely palliative procedure
4. End Stage Renal Disease (Dialysis, pre-dialysis or conservatively managed CKD Stage 5)
5. Known allergy to iodinated radiological contrast agents
6. Unable to consent/lacks capacity

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Glomerular filtration rate (eGFR) using the CKDEpi creatinine formula at baseline and 3 months.

Secondary Outcome Measures

Name	Time	Method
<br> 1. Renal function is measured using serum creatinine based eGFR (CKD-Epi), cystatin c based eGFR (CKDEpi) and Iohexol clearance at baseline, 3 months and 1 year post-operatively<br> 2. Occurence of proteinuria or micro-albuminuria measured at baseline, 3 months and 1 year post-operatively<br>