EUCTR2007-005685-12-AT进行中（未招募）不适用
The influence of hormone replacement therapy on the cerebral serotonin-1A receptor distribution and mood in postmenopausal women - Hormone replacement therapy and serotonin-1A receptors
niversitätsklinik für Psychiatrie und Psychotherapie, Klin. Abteilung f. Biologische Psychiatrie0 个研究点开始时间: 2008年7月7日最近更新:
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相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- Female
入选标准
- •Postmenopausal females in good condition (over 14 months of amenorrhoea)
- •Age 50 - 65 years
- •Uni- or Multipara
- •Signed informed consent form
- •Consent not to participate in PET or SPECT studies with an added equivalence dose of over 15 mSv within 10 years following the final assessment of the participant in this study.
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
排除标准
- •Steroid hormone treatment within 6 months prior to the inclusion
- •Current substance abuse
- •History of any malign illness
- •Any implant or stainless steel graft
- •Concomitant neurological illness
- •Concomitant psychiatric disorder except anxiety disorders or depression
- •Treatment with a psychotropic agent targeting serotonin-1A and serotonin-2A receptors or the serotonin transporter such as buspirone, pindolol or SSRIs.
- •Clinically relevant abnormalities in the general physical examination and the routine laboratory screening
- •Concomitant major illness, especially: liver disease, disorder of the endocrine system, osteoporosis (when treated with vitamine D), any clinically relevant vascular or heart diseases
- •One of the following gynaecological diseases: ovariectomy, hysterectomy, endometriosis, myomatosis, cervical smear test: PAP > II
- •Extensive obesity (limiting factor is the bore of the MRI scanner)
- •Failures to comply with the study protocol or to follow the instructions of the investigating team.
- •Investigations using PET or SPECT within 10 years prior to the inclusion.
研究者
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