The effect of hormonal replacement therapy on menopausal complaints related to biochemical changes in surgically and naturally postmenopausal women. A prospective observational comparative study.
Completed
- Conditions
- menopause1003860810074469
- Registration Number
- NL-OMON30054
- Lead Sponsor
- Antoni van Leeuwenhoek Ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 280
Inclusion Criteria
gr 1) Eligible to undergo PBSO
Either proven BRCA 1 or BRCA 2 mutation carrier or member of an HBOC-
family
gr 2) Last menses >3 months ago
Menopausal complaints
gr 3) Age>=46 and <56 years
Last menses >3 months, <3 years
Exclusion Criteria
gr 2 : Hormone use (contraceptives or HRT)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Endocrine symptoms score<br /><br>Hot flush score<br /><br>Estrogens, Testosterone, DHEAS, Serotonine, 5-HT2A-receptor</p><br>
- Secondary Outcome Measures
Name Time Method <p>Sexual functioning score<br /><br>Depression and anxiety score<br /><br>Progesterone, LH, FSH, Cortisol, SHBG, Prolactin, Oxytocin, Catecholamines and<br /><br>β-Endorphin</p><br>