Comparison of two anesthetic agents in electric shock therapy for psychiatric illnesses

Not yet recruiting

• Conditions: Psychiatric patients

• Registration Number: CTRI/2018/08/015218
• Lead Sponsor: Samiksha kumari

Brief Summary

**A  COMPARATIVE  STUDY OF  ETOMIDATE  AND PROPOFOL  AS  INDUCTION AGENTS  IN  MODIFIED ELECTROCONVULSIVE THERAPY**

**INTRODUCTION:** Modified ECT is used in refractory psychiatric illnesseswith anaesthesia to avoid trauma to the patient physically and psychologically.Propofol and etomidate are short acting iv anaesthetic agents used in ECT.

**AIMS AND OBJECTIVES:** 1) To studypropofol in terms of induction time, motor seizure duration, hemodynamicparameters, recovery time and adverse effects. 2)To study etomidate in terms of induction time, motor seizure duration, hemodynamicparameters, recovery time and adverse effects. 3)Comparison of propofol and etomidate in terms of induction time, motorseizure duration, hemodynamic parameters, recovery time, adverse effects inmodified electroconvulsive therapy.

**MATERIAL AND METHODS:** The study will be conducted inDepartment of Anaesthesiology, GGS Medical College, Faridkot. **INCLUSION CRITERIA** 1)Adultpatients of equal number of males and females, aged between 18 and 55 years. 2)Patientsbelonging to American Society of Anesthesiologist Grade I and II. 3)Patientsscheduled for electroconvulsive therapy. **EXCLUSIONCRITERIA** 1)Patientor relatives refusal for electroconvulsive therapy or both. 2)Patients with known allergy to thestudy drug. 3)Patients with full stomach,neuromuscular disorders, displaced bone fractures, severe osteoporosis.3)Patients with history of recent myocardial infarction (<3 months), recentcerebrovascular accident or raised ICP. 4)Patients with epilepsy 5)Patientswith hypopituitarism and major illnesses like bronchial asthma andtuberculosis. 6)Pregnant patients. 7)Agitated patients requiring additionalsedation. 7)ASA grade III and IV patients.

Writteninformed consent will be obtained from each patient. 70 patients scheduled forelectroconvulsive therapy at Department of Anaesthesia, GGSMCH, Faridkot willbe randomly assigned to one of two general anaesthetic groups.

GroupA patients will recieve propofol 1.0 mg/kg and Group B patients will receive etomidate0.2 mg/kg as induction agents respectively and motor seizure duration of thetwo drugs will be measured.

Intra–operatively, motor seizure duration, induction time, hemodynamic and recoveryparameters and any adverse effects will be noted. Following ECT, patients willbe assessed by patient satisfaction score and emergence agitation score.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2018-06-08
• Study Start: 2018-08-20

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• 1)Adult patients of equal number of males and females, aged between 18 to 55 years.
• 2)Patients belonging to American Society of Anesthesiologist Grade I and II.
• 3)Patients scheduled for electroconvulsive therapy.

Exclusion Criteria

• 1)Patient or relatives refusal for electroconvulsive therapy or both.
• 2)Patients with known allergy to the study drug.
• 3)Patients with full stomach, neuromuscular disorders, displaced bone fractures, severe osteoporosis.
• 4)Patients with history of recent myocardial infarction (<3 months), recent cerebrovascular accident or raised ICP.
• 5)Patients with epilepsy 6)Patients with hypopituitarism and major illnesses like bronchial asthma and tuberculosis.
• 7)Pregnant patients.
• 8)Agitated patients requiring additional sedation.
• 9)ASA grade III and IV patients.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measurement of motor seizure duration in isolated limb in seconds for both the drugs	Measurement of motor seizure duration in isolated limb in seconds just after giving electric shock for both the drugs

Secondary Outcome Measures

Name	Time	Method
Recovery parameters	Any side effects

Trial Locations

Locations (1)

Guru Gobind Singh hospital Faridkot; 🇮🇳 Faridkot, PUNJAB, India

Guru Gobind Singh hospital Faridkot

🇮🇳Faridkot, PUNJAB, India

Samiksha Kumari

Principal investigator

9876922625

drsamiksha309@gmail.com