Combination of Platelets Rich Plasma and Hyaluronic is an Effective Tool for Treatment of Knee Osteoarthritis

Not Applicable

Completed

• Conditions: Knee Osteoarthristis
• Interventions: Drug: Hyaluronic Acid (HA); Drug: Platelet Rich Plasma; Drug: Hyaluronic Acid (HA) and Platelet rich plasma

• Registration Number: NCT07089446
• Lead Sponsor: University of Karachi

Brief Summary

The purpose of the study is to determine the effects of HA, PRP and the combination of HA and PRP in reducing pain and improving functional disability in patients with knee osteoarthritis.

Detailed Description

To determine the effects of combination of platelet rich plasma (PRP) and hyaluronic acid and the PRP or HA alone in reducing pain and increasing range of motion among individuals with knee osteoarthritis.

Study Timeline

• Study Start: 2022-09-21
• Primary Completion: 2025-05-02
• Study Completion: 2025-06-15
• Status Verified: 2025-07
• Study First Submitted: 2025-07-20
• Study First Submitted QC: 2025-07-20
• Last Update Submitted: 2025-07-20
• Study First Posted: 2025-07-28
• Last Update Posted: 2025-07-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• grade II-III according to the Kellgren-Lawrence classification),
• pain or functional limitations in patients' activity of daily living before the treatment,
• age between 40 and 70 years of age, and the absence of clinical or imaging signs of articular instability.

Exclusion Criteria

• includes known hypersensitivity to hyaluronic acid,
• pregnancy and lactation, a BMI greater than 40 kg/m2,
• chronic administration of anticoagulant drugs or a history of coagulopathies,
• neoplastic lesions, and knee or kidney failures

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group A	Hyaluronic Acid (HA)	Hyaluronic acid
Group B	Platelet Rich Plasma	platelet rich plasma
Group C	Hyaluronic Acid (HA) and Platelet rich plasma	Hyaluronic acid and platelet rich plasma

Primary Outcome Measures

Name	Time	Method
visual analogue scale	Recorded before the treatment and repeated within 3 and 6 months after the treatment.	It is a straight line, 100 millimeters long line, one end of the line means "not at all" or "none" and the other end means "the worst possible" or "extremely".

Secondary Outcome Measures

Name	Time	Method
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)	Recorded before the treatment and repeated within 3 and 6 months after the treatment.	It s a questionnaire used to assess pain, stiffness, and physical function in individuals with osteoarthritis, particularly of the knee. It is a self-administered, multidimensional tool that evaluates these three dimensions through a series of questions, typically on a Likert scale.

Trial Locations

Locations (1)

South City Hospital; 🇵🇰 Karachi, Sindh, Pakistan