Effect of Varaasanadi kwatha and Vidanganagaradi churna in reducing Body Mass Index (BMI) of Poly Cystic Ovarian Syndrome patients.

Polycystic Ovarian Syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive age, characterized by ovulatory dysfunction, hyperandrogenism, and polycystic ovaries. It presents with short-term consequences including infertility, irregular menstrual cycles, obesity, and metabolic disturbances, with long-term risks including cardiovascular diseases and Type 2 diabetes mellitus. Management strategies predominantly involve weight loss interventions alongside pharmacological treatments. This clinical trial proposes the evaluation of traditional Ayurvedic formulations, Varaasanadi Kwatha and Vidanganagaradi Choorna, for their efficacy in managing PCOS. These formulations, are predominantly Kaphamedohara , Katu Tiktha Kashaya rasa pradhana Tikshna guna ,ushna virya and katu vipaka . hold promise in acting as both Sthoulyahara and Arthavapravarthaka. Study design is an Interventional pre- and post-study with a targeted sample size of 28 participants. Eligible female subjects aged 18-45 years, diagnosed with Polycystic Ovarian Syndrome, are recruited from the Outpatient Department of Prasutitantra and Streeroga at the Government Ayurveda College Hospital in Tripunithura. Data collection involves clinical observation using a structured case proforma and conducting relevant investigations. The intervention includes administering 48 ml of Varaasanadi Kwatha twice daily before meals and 6 grams of Vidanganagaradi Choorna with 6 grams of honey as anupana twice daily before meals over a 90-day period. Assessment occurs on the 0th and 91st days, focusing on changes in Body Mass Index, Waist Circumference, ovarian morphology via ultrasound, and PBAC (Pictorial Blood Assessment Chart) score, which evaluates menstrual cycle characteristics. Additionally, participants undergo reviews on the 31st and 61st days, primarily examining changes in Body Mass Index, Waist Circumference, and PBAC score.