Atrial Strain in Septic Shock

Not yet recruiting

• Conditions: Septic Shock; Left Atrial Strain; Right Atrial Strain; Transthoracic Echocardiography; Speckle Tracking; Echocardiographic Software; Reproducibility; Critical Care

• Registration Number: NCT06832436
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Septic shock is a critical condition associated with high mortality. Transthoracic echocardiography is widely used to evaluate cardiac function and guide treatment. Left and right atrial strain (LAS and RAS) measured via speckle tracking echocardiography have shown prognostic value in cardiovascular diseases. However, differences exist between echocardiographic software, leading to challenges in result comparability. This study aims to compare LAS and RAS measurements between ECHOPAC and UWS software, evaluate AutoStrain technology, and assess reproducibility across observers. The study is non-interventional and will use retrospective echocardiographic data from patients treated for septic shock. The findings will contribute to improving measurement standardization in critically ill patients.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-02
• Study First Submitted: 2025-02-11
• Study First Submitted QC: 2025-02-11
• Last Update Submitted: 2025-02-11
• Study First Posted: 2025-02-18
• Last Update Posted: 2025-02-18
• Study Start: 2025-03-01
• Primary Completion: 2025-09
• Study Completion: 2026-03

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Age: >18 years
• Adult patients admitted to critical care for septic shock (SEPSIS-3 definition)
• TTE performed as part of medical management
• No objection to data usage

Exclusion Criteria

• Pregnancy
• Moderate to severe valvular regurgitation/stenosis (>grade 2)
• Ventricular or supraventricular tachyarrhythmia (HR >140 bpm) at the time of TTE
• Poor echogenicity preventing LAS measurement
• Mechanical circulatory support
• Pacemaker dependence
• Patients under guardianship

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
variation of LASr between ECOPAC and UWS	1 year	Agreement of LAS Reservoir Phase (LASr) measurement in manual mode between ECHOPAC and UWS

Secondary Outcome Measures

Name	Time	Method
variation of LAScd between ECHOPAC and UWS	1 year	Comparison of LAS Conduit (LAScd) measurements in manual mode between ECHOPAC and UWS
variation of LASct between ECHOPAC and UWS	1 year	Comparison of LAS Conduit (LAScd) and Contraction (LASct) measurements in manual mode between ECHOPAC and UWS
Comparison of LASr measurements in apical 2-chamber views	1 year	Comparison of LASr measurements in apical 2-chamber views in manual mode between ECHOPAC and UWS
Comparison of LAScd measurements in apical 2-chamber views	1 year	Comparison of LAScd measurements in apical 2-chamber views in manual mode between ECHOPAC and UWS
Comparison of LASct measurements in apical 2-chamber views	1 year	Comparison of LASct measurements in apical 2-chamber views in manual mode between ECHOPAC and UWS
Comparison of right atrial strain RASr between ECHOPAC and UWS	1 year	Comparison of right atrial strain (RASr) in manual mode between ECHOPAC and UWS
Comparison of right atrial strain RAScd between ECHOPAC and UWS	1 year	Comparison of right atrial strain RAScd in manual mode between ECHOPAC and UWS
Comparison of right atrial strain RASct between ECHOPAC and UWS	1 year	Comparison of right atrial strain RASct in manual mode between ECHOPAC and UWS
Comparison of LAS in AutoStrain versus manual mode	1 year	Comparison of LAS measurements in AutoStrain versus manual mode on UWS
Comparison of RAS in AutoStrain versus manual mode	1 year	Comparison of RAS measurements in AutoStrain versus manual mode on UWS
Comparison of LAS measurements in AutoStrain (UWS) versus manual mode on ECHOPAC	1 year	Comparison of LAS measurements in AutoStrain (UWS) versus manual mode on ECHOPAC
Comparison of RAS measurements in AutoStrain (UWS) versus manual mode on ECHOPAC	1 year	Comparison of RAS measurements in AutoStrain (UWS) versus manual mode on ECHOPAC
Assessment of differences in LAS measurements at end-diastole between ECHOPAC and UWS	1 year	Assessment of differences in LAS phase measurements between ECHOPAC and UWS
Assessment of differences in LAS measurements at pre-A between ECHOPAC and UWS	1 year	Assessment of differences in LAS measurements at pre-A between ECHOPAC and UWS
Assessment of differences in RAS measurements at end-diastole between ECHOPAC and UWS	1 year	Assessment of differences in RAS measurements at end-diastole between ECHOPAC and UWS
Assessment of differences in RAS measurements at pre-A between between ECHOPAC and UWS	1 year	Assessment of differences in RAS measurements at pre-A between between ECHOPAC and UWS
Inter-observer reproducibility assessment of manual measurements (UWS and GE) in a sample of 10 patients	1 year	Inter-observer reproducibility assessment of manual measurements (UWS and GE) in a sample of 10 patients
Intra-observer reproducibility assessment of manual measurements (UWS and GE) in a sample of 10 patients	1 year	Intra-observer reproducibility assessment of manual measurements (UWS and GE) in a sample of 10 patients
Inter-observer reproducibility assessment of AutoStrain measurements (UWS and GE) in a sample of 10 patients	1 year	Inter-observer reproducibility assessment of AutoStrain measurements (UWS and GE) in a sample of 10 patients
Intra-observer reproducibility assessment of AutoStrain measurements (UWS and GE) in a sample of 10 patients	1 year	Intra-observer reproducibility assessment of AutoStrain measurements (UWS and GE) in a sample of 10 patients

Trial Locations

Locations (1)

CHRU Amiens; 🇫🇷 Salouel, France