The Role of Blood Purification by Hemoadsorption as Adjunctive Treatment in Children with Septic Shock
- Conditions
- Children with septic shock and multi organ dysfunctionseptic shock, blood purification, hemoperfusion using cytokine adsorption, hemoadsorption, HA330, pediatric intensive care, PELOD-2 score, PRISM-3 score
- Registration Number
- TCTR20220602002
- Lead Sponsor
- Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University
- Brief Summary
The PELOD-2 score in HA group was significantly lower than that in the control group at 72 hours but there was no significant difference in PRISM-3 score between 2 groups. In the HA group had significantly reduction of IL-6 from 206.4 pg/mL at baseline to 37.4 pg/mL at 72 hours. There was no significant difference in VIS, PCT, CRP, lactate levels, length of PICU stay, mechanical ventilator days or hospital stay between the groups.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 12
Patients were included if they: 1.are 30 days to 15 years of age, 2.require any dose of at least one vasopressor and 3. has a Pediatric Logistic Organ Dysfunction (PELOD)-2 score more than 10 or Pediatric Risk of Mortality (PRISM)-3 score more than 15
Patients receiving end-of-life support, those with uncontrolled bleeding were excluded.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mortality score 72 hours after the intervention The reduction of PELOD-2 score and PRISM-3 score
- Secondary Outcome Measures
Name Time Method Vasoactive inotropic score (VIS) 72 hours after the intervention The reduction of VIS score,Inflammatory markers 72 hours after the intervention IL-6, procalcitonin, CRP, lactate levels,other outcomes 2 years after start the enrollment PICU length of stay, duration of mechanical ventilator, hospital stay and 28-day mortality