A Study to determine the efficiency of a specific modality of ultrasound (tissue doppler imaging) in imaging an abddominal muscle (diaphragm) to predict if patients can be successfully liberated from ventilator

Not yet recruiting

• Conditions: Respiratory disorder, unspecified,

• Registration Number: CTRI/2020/12/029533
• Lead Sponsor: Gautham Chandran

Brief Summary

A propsective observational study

aimed at determining the utility of a specific mode of ultrasound (Tissue Doppler Imaging) in predicting weaning in critically ill patients receiving mechanical ventilation in ICU.

Enrollment not started

study duration approximately 2 years

study size 40

Institute Ethics committe approval received on 22.7,20

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2020-11-29
• Study Start: 2020-12-15

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• On mechanical ventilation >48hrs. Readiness for weaning from mechanical ventilation Recovery from the cause of respiratory failure Stable hemodynamic parameters. Low or no vasopressor requirement No sedative agents or NMBA > 24 h before enrolment. Patients who meet criteria for spontaneous breathing trial Fio2 < 40 Pressure Support (PS) < 10 Positive End Expiratory Pressure (PEEP) < Respiratory Rate <30 P/F ratio >200 Glasgow coma scale.
• GCS >14 , RASS: -2 to +2.

Exclusion Criteria

• Pregnant Women Presence of Pneumothorax or Ascites H/o either neuromuscular disease, thoracic surgery, Diaphragmatic Palsy, Cervical Spine Injury Weaning failure definitely caused by upper airway obstruction Planned prophylactic NIV after extubation.
• Poor ultrasound windows and image.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine the diagnostic accuracy of diaphragmatic pulse-wave tissue doppler imaging (PW-TDI) parameters in predicting weaning outcomes in critically ill mechanically ventilated patients	Ultrasound measurements will be taken at the end of a 60 minute spontaneous breathing trial

Secondary Outcome Measures

Name	Time	Method
Length of hospital stay.

Trial Locations

Locations (1)

All India Institute Of Medical Sciences; 🇮🇳 South, DELHI, India

All India Institute Of Medical Sciences

🇮🇳South, DELHI, India

Gautham Chandran

Principal investigator

9004978187

gautham.chandran@gmail.com