Effects of Barley Based Food Products on Metabolism and Gut Microflora
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Changes in colonic microbiota composition after intervention with barley
研究概览
简要总结
The main objective is to investigate gut microflora composition in relation to cardiometabolic risk markers, and to investigate the effects of 3 days intervention with a barley kernel based product on these variables.
详细描述
100 subjects were invited to deliver faecal samples. From this cohort 40 subjects were chosen based on their gut microflora composition to participate in the Barley intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy men and women between 50-79 years and
- •BMI between 19-28.
排除标准
- •fasting blood glucose concentrations > 6,1 mmol/L,
- •known metabolic disorders or gastrointestinal diseases or other disorders that can interfere with the results of the study.
- •furthermore, the subjects should be non-smokers and
- •consume a normal (non-vegetarian) diet as is recommended by the Nordic dietary guidelines.
- •antibiotics or probiotics should not have been taken during four weeks prior to faeces donation.
结局指标
主要结局
Changes in colonic microbiota composition after intervention with barley
时间窗: Changes in colonic microbiota composition after 3 days intervention with a barley based bread in comparison to 3 days intervention with a white wheat based bread
Gut microbiota composition are characterised after interventions with barley based bread and white wheat bread, respectively
Changes in glucose regulation
时间窗: Changes in fasting and postprandial blood glucose concentrations after 3 days intervention with a barley based bread in comparison to 3 days intervention with a white wheat based bread
blood glucose concentrations are measured fasting and postprandially a standardised breakfast after interventions with barley based bread and white wheat bread, respectively
nucleotide polymorphisms (SNP in TCF7L2)
时间窗: at baseline
investigate nucleotide polymorphisms that associate with cardiometabolic traits, in particular the SNP in TCF7L2
次要结局
未报告次要终点
研究者
Anne Nilsson
Associate professor, PhD
Lund University