Production of Gut Microbiota-Derived Metabolites in Response to Different Fatty Acid Profiles
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 49
- 试验地点
- 2
- 主要终点
- Fasting and postprandial lipid metabolite production in response to dietary lipid intervention in abdominal obesity and type 2 diabetes
研究概览
简要总结
The proposed project mainly aims to investigate the microbial processes leading to dietary metabolites production, independently of long-term microbiota adaptation to the diet, by measuring the microbiota-derived metabolite production from a meal sequence rich in saturated fatty acids (SFA) or the same meals but rich in polyunsaturated fatty acids (PUFA) in individuals with or without obesity and Type 2 diabetes (T2D)
详细描述
The gut microbiota interacts with the host's enteric and systemic functions through the production of gut microbiota-derived metabolites. A subset of these metabolites, the endocannabinoids (eCB) and their congeners are derived from fatty acids and play a crucial role in metabolic health.
The research project aims to study gut microbiota-derived metabolites, including the eCB and their congeners, in response to a 2-day diet rich in polyunsaturated fatty acids or rich in saturated fatty acids in individuals with or without abdominal obesity and type 2 diabetes.
The investigators hope to better understand the kinetic production of circulating endocannabinoidome mediators derived from fatty acids in the diet.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Sequential
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women aged between 45 and 65 years, menopaused women ;
- •Body mass index between 20 to 35 kg/m² ;
- •General good health ;
- •Score of diet quality (HEI) between 40 and 70 ;
- •Computer and Internet access ;
- •Basic understanding of written French ;
- •Daily stool frequency.
排除标准
- •Intestinal pathologies including inflammatory bowel disease and gastrointestinal cancers ;
- •Alcohol consumption greater than 15 portions for men and 10 for women weekly.
- •Active tobacco and cannabis usage ;
- •Consumption of omega-3 dietary supplements ;
- •Consumption of dietary supplements (vitamins and probiotics) - must be ceased 2 weeks before the dietary intervention ;
- •Completion of a course of antibiotics in the past 3 months ;
- •Important weight change (+/- 5 kg) in the past 6 months ;
- •Type 1 diabetes or insulin-treated diabetes.
结局指标
主要结局
Fasting and postprandial lipid metabolite production in response to dietary lipid intervention in abdominal obesity and type 2 diabetes
时间窗: 7 days
Interindividual variations in the endocannabinoidome mediators levels following a 2-day SFA and UFA diet intervention according to abdominal adiposity and type 2 diabetes.
次要结局
- Gut microbiota in response to a 2 day dietary lipid intervention in abdominal obesity and type 2 diabetes(7 days)