The Influence of Sweet Substrates on Hunger, Gastrointestinal Hormones and the Migrating Motor Complex

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: 25g fructose; Dietary Supplement: 50g glucose; Dietary Supplement: 220mg acesulfame-K; Dietary Supplement: 250mL tap water

• Registration Number: NCT02891525
• Lead Sponsor: Universitaire Ziekenhuizen KU Leuven

Brief Summary

In this study, the investigators aimed at evaluating the role of sweet taste receptors in the gastrointestinal tract (GIT). Intragastric administration of glucose, fructose or acesulfame-K were compared with placebo administration for their effects on gastrointestinal motility, gut hormone release (motilin, ghrelin, glucagon-like peptide-1 (GLP-1) and insulin) and hunger feelings.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-03
• Primary Completion: 2016-02
• Status Verified: 2016-06
• Study First Submitted: 2016-09-01
• Study First Submitted QC: 2016-09-01
• Last Update Submitted: 2016-09-01
• Study First Posted: 2016-09-07
• Last Update Posted: 2016-09-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• BMI<30 kg/m² for the lean volunteers
• Female or male subjects aged 18 to 60
• Subject is capable and willing to give informed consent
• Female volunteers of child bearing potential must use oral, injected or implanted hormonal methods of contraception

Exclusion Criteria

• Female volunteer is pregnant or breastfeeding
• GI diseases, major abdominal surgery
• Volunteers that have food allergies, especially fructose intolerance
• Major psychiatric illnesses
• Volunteers that use drugs affecting the GI tract or the central nervous system
• Volunteers suffering from an endocrine disease such as diabetes, Cushing's disease, Addison's disease, hypothalamic tumor
• Volunteers that have undergone surgical procedure for weight loss

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
25g fructose intragastric	25g fructose	25g glucose dissolved in 250mL tap water given via nasogastric tube
50g glucose intragastric	50g glucose	50g glucose dissolved in 250mL tap water given via nasogastric tube
220mg acesulfame-K intragastric	220mg acesulfame-K	220mg acesulfame-K dissolved in 250mL tap water given via nasogastric tube
250mL tap water intragastric	250mL tap water	250mL tap water given via nasogastric tube

Primary Outcome Measures

Name	Time	Method
Change in gastrointestinal motility measured by antroduodenal high-resolution manometry	3 hours after administration, continuous measurement with high resolution manometry

Secondary Outcome Measures

Name	Time	Method
Change in gut hormone release measured by specific radioactive immunoassays	3 hours after administration, blood sample every 15 min
Change in subjective hunger and satiety scores measured by visual analogue scales of 100 mm	3 hours after administration, assessment every 5 min