The Acute Effect of Statins on Inflammatory Markers of Athersclerotic Tissue
- Registration Number
- NCT00587717
- Lead Sponsor
- Mayo Clinic
- Brief Summary
This study is being done to determine if the acute administration of the drug Simvastatin reduces plaque tissue inflammation and plaque instability in patients undergoing carotid endarectomy
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 35
Inclusion Criteria
- Patients undergoing carotid endarterectomy
- No previously known side effects of statins
- Patients who will sign an informed consent
- Age > 18 years old
- No signs of current infection
Exclusion Criteria
- Patient hypersensitive to any component of this medication
- Patients with acute liver disease (AST> normal value)
- Patients with chronic liver disease (history of Hepatitis B or C)
- Patients with renal failure (creatinine > 3.0)
- Patients with unexplained muscle pains and aches
- Patients with rheumatoid arthritis
- Patients with Lupus
- Current cancer treatment
- Patients on cyclosporin, digoxin, Itraconazole, Ketoconazole and other antifungal azoles, the macrolide antibiotics and antidepressant nefazodone
- Pregnant females
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 2 placebo Two 80 mg pills placebo are taken 24 hours prior to surgery 1 simvastatin Two 80 mg pills simvastatin taken 24 hours prior to surgery
- Primary Outcome Measures
Name Time Method This study is being done to see if giving the study drug, Simvastatin, quickly lessens the swelling of plaque tissue (tissue around your heart) and plaque movement in patients undergoing cqrotid endarterectomy procedure. 24 prior to surgery
- Secondary Outcome Measures
Name Time Method