ACTRN12622000279729进行中（未招募）未知
Postoperative pulmonary complications (atelectasis and pneumonia) in the ENIGMA 2 Trial
适应症
试验速览
- 阶段
- 未知
- 状态
- 进行中（未招募）
- 入组人数
- 2,325
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 45 Years 至 o limit（—）
- 性别
- All
入选标准
- •Participants randomised to the ENIGMA 2 Trial within Australia, according to the ENIGMA 2 inclusion criteria:
- •Adult males and females age >/= 45 years, undergoing noncardiac surgery and general anaesthesia expected to exceed two hours.
- •At increased risk of cardiac events, defined as any of
- •history of coronary artery disease as defined by a history of any one of the following: i. angina ii. MI iii. segmental wall motion abnormality on echocardiography or a fixed defect on radionuclide imaging iv. a positive exercise stress test for cardiac ischaemia v. a positive radionuclide exercise, echocardiographic exercise, or pharmacological cardiovascular stress test for cardiac ischaemia vi. coronary revascularization (CABG or PTCA) vii. angiographic evidence of atherosclerotic stenosis > 50% of the diameter of any coronary artery viii. ECG with pathological Q waves in two contiguous leads
- •heart failure
- •cerebrovascular disease thought due to atherothrombotic disease
- •aortic or peripheral vascular disease
- •or three or more of the following risk factors:
- •age >/=70 years
- •any history of congestive heart failure
- •diabetes and currently on an oral hypoglycaemic agent or insulin therapy
- •current treatment for hypertension
- •preoperative serum creatinine >175 micro mol/L (> 2.0 mg/dl)
- •current or previous high cholesterol >6.2 mmol/L (> 240 mg/dl)
- •history of a transient ischemic attack (TIA) (i.e. a transient focal neurological deficit that lasted less than 24 hours and thought to be vascular in origin)
- •emergency/urgent surgery (i.e. surgery which must be undertaken within 24 hours of acute presentation to hospital) high-risk type of surgery (i.e. intrathoracic or intraperitoneal)
排除标准
- •having cardiac surgery
- •marked impairment of gas-exchange expected to require Fi02> 0.5 intraoperatively
- •specific circumstances where N2O is contraindicated (eg. volvulus, pulmonary hypertension, raised intracranial pressure) or the anaesthetist plans to use supplemental oxygen (eg. colorectal surgery)
- •N2O unavailable for use.
研究者
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