A Study on Central Transport Characteristics of Flurbiprofen Axetil in Elderly Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 77
- 试验地点
- 1
- 主要终点
- The concentrations of S-flurbiprofen and R-flurbiprofen in plasma and CSF of all patients.
研究概览
简要总结
The project will apply the methods of clinical observation experiment to study the central transport characteristics of flurbiprofen axetil by detecting S-flurbiprofen and R-flurbiprofen concentrations in cerebral-spinal fluid(CSF) after intravenous injection of flurbiprofen axetil in elderly patients.
详细描述
The patients undergoing spinal anesthesia for lower extremity surgery will be studied. Flurbiprofen axetil 100mg will be injected intravenously. CSF 1ml and blood 2ml will be obtained simultaneously every 5 minutes after intravenous injection in 50 min( T1~T10).CSF and blood samples will be used to detected S-flurbiprofen and R-flurbiprofen concentrations by using Liquid Chromatography-Mass Spectrometry. And the CSF/blood S-flurbiprofen and R-flurbiprofen concentrations ratio were calculated.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients undergoing lower extremity surgery under spinal or combined spinal-epidural anesthesia will be selected.
排除标准
- •asthma, liver insufficiency, renal insufficiency, peptic ulcer, allergy to NSAIDs, and a history use of NSAIDs within two weeks before operation.
结局指标
主要结局
The concentrations of S-flurbiprofen and R-flurbiprofen in plasma and CSF of all patients.
时间窗: perioperation
The samples will be used to be determined plasma and CSF drug concentrations.
次要结局
未报告次要终点
研究者
Yi Feng, MD
Director of department of anesthesiology and painmanagement
Peking University People's Hospital