A clinical trial to study the effects of Leukocyte platelet rich fibrin (blood concentrate) on orthodontic tooth movement.

Not Applicable

Conditions: Health Condition 1: R688- Other general symptoms and signs

Registration Number: CTRI/2020/10/028463

Lead Sponsor: All India Institute of Medical Sciences Bhubaneswar

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

Female subjects having Class I bimaxillary protrusion malocclusion with normodivergent growth pattern (FMA, 200-250),minimum crowding

or spacing in maxillary and mandibular arches, and require all 1stpremolarextraction for the correction of her malocclusion.Presence of full complement of teeth except 3rd molars.Good oral hygiene (Probing depth <3mm, Gingival index score <1)

Exclusion Criteria

History of previous orthodontic treatment,

Subject who fails to maintain good oral hygiene during orthodontic treatment,

Subjects with pregnancy,

Subjects having any known syndrome or metabolic disorder affecting calcium and phosphate metabolism,

Medication like NSAIDs,

Lack of manual dexterity,

Having medications for any systemic disease,

Known blood disorder like thrombocytopenia, leukopenia etc.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Acceleration of orthodontic treatmentTimepoint: prior to premolar extraction(T0), after 4 weeks after premolars extraction (T1), 8-weeks (T2), 12-weeks (T3) and 16-weeks (T4) after premolar extraction.

Secondary Outcome Measures

Name	Time	Method
Associated elevation of expression of IL-1Î² and TNF-Î± in gingival crevicular fluid distal to canines on experimental and control sideTimepoint: prior to premolar extraction(T0), after 4 weeks after premolars extraction (T1), 8-weeks (T2), 12-weeks (T3) and 16-weeks (T4) after premolar extraction.