The effect of autologous leukocyte platelet rich fibrin (LPRF) on the rate of orthodontic tooth movement- a prospective randomized clinical trial

Not Applicable

• Conditions: orthodontic tooth movement.; Other specified medical care

• Registration Number: IRCT2015100724405N1
• Lead Sponsor: Dental Research Center

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

Inclusion Criteria: more than12 years old patients; bilaterally symmetric extraction of premolar teeth; no medicines or systemic illness; full banding/bonding of teeth in both arches.

Exclusion Criteria

pregnancy; non-extraction treatment; syndromic &systemic illness or medication like NSAIDS that interfere with OTM; prior orthodontic treatment.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The amount of tooth movementand to compare the amount of tooth movement between maxillary and mandibular arches. Timepoint: [Time Frame: 0 days, 15 days, 1st month, 1.5 and 2nd month, 2.5 and 3rd month after start of treatment and conventional orthodontic]. Method of measurement: The amounts of OTM will be measured by comparing the changes of distance between the adjacent teeth in two weeks interval for three months. The exact amounts of tooth movement will be measured clinically by Boley Gauge Caliper with sharp tips located at the CEJ of crowns of the casts and then will be compared and double checked by another independent blind examiner ( to evaluate the interobserver and intraobserver reliability).

Secondary Outcome Measures

Name	Time	Method
Mucogingival defects, gingival recession, clinical attachement loss, probing depth, width of keratinized gingiva. Timepoint: Time Frame: 0 days, 15 Days, 1st month, 1.5 month. Method of measurement: aesculap periodontal probe.