PRF on acceleration of orthodontic tooth movement
- Conditions
- Health Condition 1: K088- Other specified disorders of teethand supporting structures
- Registration Number
- CTRI/2021/03/031620
- Lead Sponsor
- Iswariya A
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Subjects having Class I bimaxillary dentoalveolar protrusion malocclusion or Class II div 1 malocclusion with normo-divergent growth pattern (FMA 20Ë?- 28Ë?), minimum crowding or spacing in maxillary and mandibular arches who require either all 1st premolars or only upper 1st premolars extraction for the correction of their malocclusion.
-Presence of full complement of teeth except 3rd molars.
-Good oral hygiene (probing depth <3mm, gingival index score <1).
-History of complete or incomplete comprehensive orthodontic treatment.
-Subject who fails to maintain good oral hygiene all through the orthodontic treatment.
-Subjects with pregnancy.
-Subjects having any known syndrome or metabolic disorder affecting calcium and phosphate metabolism.
-Subjects on long term medications like NSAIDâ??S or steroids.
-Lack of manual dexterity.
-Any medications for systemic illness.
-History of recent bacterial or viral infection.
-Known blood disorders like thrombocytopenia, leukopenia etc.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Increase in the expression of interleukin 6 on the experimental side. <br/ ><br>Increase in the rate of maxillary canine retraction on the experimental side. <br/ ><br>Timepoint: T0(before L-PRF placement) <br/ ><br>T1(1 week after L-PRF placement) <br/ ><br>T2(2week after L-PRF placement) <br/ ><br>T3(4week after L-PRF placement) <br/ ><br>T4(8week after L-PRF placement)
- Secondary Outcome Measures
Name Time Method correlation between the concentration of IL-6 in GCF with the rate of canine retraction.Timepoint: T0(before L-PRF placement) <br/ ><br>T1(1 week after L-PRF placement) <br/ ><br>T2(2week after L-PRF placement) <br/ ><br>T3(4week after L-PRF placement) <br/ ><br>T4(8week after L-PRF placement)