Methoxyflurane metabolite (fluoride) presence in ambulance staff

Not Applicable

Completed

• Conditions: Fluoride accumulation; Public Health - Health service research

• Registration Number: ACTRN12617001334392
• Lead Sponsor: Dr. Paul Docherty

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-09-19
• Study Completion: 2019-07-24
• Last Update Posted: 1 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

Ambulance officers rostered in full time patient contact role. Preferential recruitment of Emergency Medical Technicians over other qualifications.

Exclusion Criteria

Staff members expected to leave the ambulance service in the course of the trial.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Statistically significant changes in serum fluoride concentration.<br>Serum fluoride will be measured by ion specific electrode in buffered venous sample.[Methoxyflurane administration by ambulance staff will commence from June 2017, following an organisational implementation plan. We will measure staff serum fluoride at 0 months after introduction (during June 2017) to establish a baseline, and at 1, 4, 8, 12, 18 and 24 (primary endpoint) months after introduction of methoxyflurane into clinical practice.]

Secondary Outcome Measures

Name	Time	Method
Rate of change in serum fluoride concentration recorded over safe levels (<= 40 µmol/L).[0, 1, 4, 8, 12, 18 and 24 months following introduction of methoxyflurane into clinical practice, as described for the primary endpoint.]