Mannitol to prevent an exacerbation of Complex Regional Pain Syndrome (CRPS) after hand surgery

Completed

• Conditions: Complex Regional Pain Syndrome (CRPS); Musculoskeletal Diseases; Algoneurodystrophy

• Registration Number: ISRCTN36315634
• Lead Sponsor: niversity Medical Centre Utrecht (UMCU) (Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-01-27
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Age at least 18 years
2. History of CRPS, indicated by the presence of the following characteristics during the past 3 years (adapted CRPS I criteria according to Bruehl):
2.1. Continuing pain, disproportionate to any inciting event
2.2. At least 1 symptom in one of the following 4 categories:
2.2.1. Sensory: hyperalgesia
2.2.2. Vasomotor: temperature asymmetry or skin color changes or skin color asymmetry
2.2.3. Sudomotor/edema: edema or sweating changes or sweating asymmetry
2.2.4. Motor/trophic: diminished range of motion or motor dysfunction or trophic changes
3. The presence of CRPS signs is not mandatory
4. Surgery on the affected upper extremity (a.o. carpal-tunnel syndrome, joint surgery on wrist and fingers)

Exclusion Criteria

1. Allergy to mannitol
2. Allergy to hydrochlorothiazide
3. Clinically relevant renal impairment (creatinine =150% normal)
4. History of cardiac failure (orthopnea, edema, exertional dyspnea, admissions for cardiac failure)
5. CRPS in both upper extremities
6. Other pain syndromes affecting functional testing or pain scores
7. Infection
8. Pregnancy
9. No informed consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified