Mannitol for acute kidney injury during liver transplantatio
Phase 3
- Conditions
- Kidney Disease
- Registration Number
- PACTR202203622900599
- Lead Sponsor
- Mansoura University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 84
Inclusion Criteria
1. Adult (= 18 years old) patients
2. Either sex
3. Undergoing living donor liver transplantation with right lobe graft from family-related donors.
Exclusion Criteria
1. Acute fulminant hepatitis
2. Estimated Graft/Recipient Weight ratio (GRWR) < 0.8
3. Portal hypertension with mean pulmonary blood pressure > 35 mmHg
4. Preoperative serum creatinine (SCr) > 1.4 mg/dl or dialysis within the last 3 months
5. Diabetes Mellitus (> 10 years)
6. Preoperative serum sodium [Na+] < 125 mEq/L and serum potassium [K+] > 5.5 mEq/L
7. Intra-operative massive blood transfusion (replacement of > 50% of total blood volume in < 3 hours)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Early acute kidney injury, defined as 0.3 mg/dl of SCr increase from the baseline in the early 48 post¬operative hours or 50% increase in the S. Cr within 48 hours.
- Secondary Outcome Measures
Name Time Method All-cause mortality;Intensive Care length of stay;intraoperative CI, SVI, MAP, MPAP, CVP, PAOP, SVR, PVR, and serum [Na+], [K+], ionized [Ca2+], and [Cl-] at 6 intraoperative times - (1) immediately before skin incision, (2) the beginning of the an-hepatic (portal vein clamping), (3) 5 minutes before portal reperfusion (basal), (4) at 5 min after portal unclamping, (5) 5 minutes a;liver graft function