HOSTAS cohort *Hand OSTeoArthritis in Secondary care* ;Inception cohort of patients with hand osteoarthritis referred to secondary care

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 538

Inclusion Criteria

•Symptomatic *primary* hand OA as diagnosed by a rheumatologist from the
outpatient rheumatology clinic of the LUMC

Exclusion Criteria

•Any other pathological condition that could explain the existing symptoms,
like tendinitis, carpal tunnel syndrome, surmenage, fibromyalgia, arthritis due
to a primarily inflammatory rheumatic disease.
•*Secondary* OA, including 1) inflammatory joint diseases, like rheumatoid
arthritis, psoriatic arthritis, spondylarthropathies and current sarcoidosis,
2) bone diseases such as osteitis deformans and osteochondritis, 3)
intraarticular fractures, 4) certain metabolic diseases associated with joint
disease such as hemochromatosis, Wilson*s disease and ochronosis, 5) endocrine
disease like acromegaly, 6) major congenital or developmental diseases and bone
dysplasias, 7) major local factors such as hypermobility, 8) severe (tophous)
gout.
•Inability to understand the Dutch language, Additional exclusion criterion
solely for the Bioelectrical Impedance Analyses (BIA) part of the physical exam
(patients who are excluded for the BIA, will not perform this part of the
physical exam, but can still participate in all the other components of
HOSTAS):
- The presence of a pacemaker or subcutaneous cardio defibrillator. ,
Additional exclusion criteria for patients who undergo MRI for the study:
- The presence of metal in the body: pacemaker or subcutaneous cardio
defibrillator, vascular clips on cerebral vessels, metallic splinters in the
eye, not removable listening aid, not removable neurostimulator,
hydrocephaluspump, dentures fixated by magnets, intra-uterine device
- Allergy for MRI contrast agents
- Impaired renal function
- Pregnancy

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>This is an descriptive study:<br /><br>1. Expositions of interest are: age, sex, profession, hand strength,<br /><br>familial/genetic factors, overweigth, symptoms, findings from physical<br /><br>examination, radiological variables, like joint space narrowing, osteophytes,<br /><br>erosions, and MRI variables, like bone marrow lesions, effusion<br /><br>2. Outcomes are: diagnosis hand osteoarthritis, disease course, both clinically<br /><br>as well as radiologically, over time, use of certain treatment modalities<br /><br>(painkillers, splints, etc.)<br /><br>3. Determinants going together with different sub-sets of hand osteoarthritis,<br /><br>like erosions, nodes, thumb base involvement, can be used as exposition as well<br /><br>as outcome in the study. </p><br>

Secondary Outcome Measures