Transcriptome-wide alterations in gene expression of the glenohumeral joint capsule in people undergoing arthroscopic surgery for adhesive capsulitis, rotator cuff tears and osteoarthritis compared to people with non-inflammatory shoulder instability

Barwon Health0 个研究点目标入组 100 人开始时间: 2018年3月26日最近更新: 2022年2月21日

适应症

试验速览

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•Inclusion Criteria (AC and control):
•Adults 18 – 70 yrs
•Symptoms > 3mths
•oMRI – exclusion of degenerative or inflammatory arthropathy, as well as stage full thickness rotator cuff tears
•Instability > 1 episode for controls, pain only a minor feature
•AC – Global loss of motion > 30%
•Inclusion criteria (rotator cuff tear)
•18 to 70 years of age
•Symptoms > 6 months (chronic tear)
•Full thickness rotator cuff tear on MRI
•Inclusion criteria (shoulder arthritis)
•18 to 85 years of age
•Primary OA
•Symptoms > 6 months
•Xray changes consistent with OA
•oOA only group: without full thickness rotator cuff tear on US or MRI
•oRotator cuff arthropathy group: x-ray indicating high humeral head

•Exclusion Criteria (AC and control):
•Post surgical restricted motion
•Instability episode < 8wks prior – for control group
•Imaging – MRI features – not fulfilling criteria
•Exclusion criteria (rotator cuff tear)
•Isolated subscapularis tears
•Reduced motion (<50% range) affecting daily living with clinical features of adhesive
•Massive tears (> 2 tendons)
•Prior shoulder surgery in the affected shoulder
•Intra-articular or intra-bursal corticosteroid injection within the preceding three months.
•Exclusion criteria (shoulder arthritis)
•Rheumatoid arthritis or seronegative arthropathies
•Type C glenoid
•Prior shoulder surgery or significant trauma/fracture
•Intra-articular or intra-bursal corticosteroid injection within the preceding three months.

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