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Clinical Trials/DRKS00006272
DRKS00006272
Completed
未知

Changes of the mRNA and microRNA expression profile of individuals with metabolic syndrome after lifestyle-induced weight loss - DIABOWLT (DIABetes Obesity Weight Loss Trial)

Institut für Klinische Chemie und Pathobiochemie Otto-von-Guericke Universität Magdeburg0 sites74 target enrollmentJuly 7, 2014
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ConditionsDIMDI: E.88.9 metabolic syndrome, metabolic disorder, unspecifiedE66.0I10.0E11Obesity due to excess caloriesType 2 diabetes mellitus

Overview

Phase
未知
Intervention
Not specified
Conditions
DIMDI: E.88.9 metabolic syndrome, metabolic disorder, unspecified
Sponsor
Institut für Klinische Chemie und Pathobiochemie Otto-von-Guericke Universität Magdeburg
Enrollment
74
Status
Completed
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
July 7, 2014
End Date
June 7, 2013
Last Updated
last year
Study Type
Interventional
Sex
Male

Investigators

Sponsor
Institut für Klinische Chemie und Pathobiochemie Otto-von-Guericke Universität Magdeburg

Eligibility Criteria

Inclusion Criteria

  • •1\. metabolic syndrome with abdominal obesity (waist circumference \> 102 cm)
  • •2\. meet two additional criteria for metabolic syndrome as defined by national Cholesterol Education Program Adult Treatmen Panel III guideliens:
  • •\- fasting TG conc. \> 150 mg/dl
  • •\- HDL\-C \< 40 mg/dl
  • •\- fasting glucose \> 110 mg/dl
  • •\- high blood pressure \>140 mmHg systolic and /or \> 90 mmHg diastolic or current treatment by anti\-hypertensive medication

Exclusion Criteria

  • •1\. Smoking
  • •2\. surgical procedure for weight loss within the previous 6 month
  • •3\. uncontrolled diabetes (HbA1c \> 10%)
  • •4\. severe renal dysfunction (creatinin concentration \> 2\.0 mg/dl)
  • •5\. active liver disease
  • •6\. obesity of known endocrine origin
  • •7\. significant haematology abnormalities
  • •8\. not able to walk at least 30 minutes per day

Outcomes

Primary Outcomes

Not specified

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