Membrane Shedding During Severe Sepsis and Septic Shock: Pathophysiological and Clinical Relevance
- Conditions
- Severe Sepsis and Septic Shock
- Registration Number
- NCT02391792
- Lead Sponsor
- University Hospital, Strasbourg, France
- Brief Summary
Microparticules (MPs) result from plasma cell membrane remodeling and shedding after cell stimulation or apoptosis. MPs are know recognized as a pool of bioactive messengers with merging role in pathophysiology of immune and cardiovascular diseases. MPs have been characterized during septic shock and may contribute to dissemination of pro-inflammatory and procoagulant mediators. This a prospective observational study of circulating MPs and blood coagulation in septic shock patients admitted in medical intensive care units (ICUs) of four tertiary hospitals at baseline (D1, D2, D3, D4, D7).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 300
Inclusion Criteria
- Septic shock (patients)
- Without septic shock (control)
- Informed consent
Exclusion Criteria
- Class IV heart failure
- Child-plugh grade C cirrhosis
- Cancer under active treatment
- BMI>35kg/m2
- Moribund patient
- DNR decision
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change from baseline in number and type of circulating microparticles at 7 days Baseline and 7 days Change from baseline in blood coagulation markers at 7 days Baseline and 7 days
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Nouvel Hopital Civil
🇫🇷Strasbourg, Alsace, France