Microcirculatory Changes During Magnesium Sulphate Infusion in Sepsis
- Registration Number
- NCT01332734
- Lead Sponsor
- Medical Centre Leeuwarden
- Brief Summary
During infections (sepsis) bloodflow in small vessels (microcirculation) becomes disturbed. Restoration of bloodpressure and cardiac performance may not be sufficient to correct these alterations. Magnesium is a potent vasodilator which may be used to open up the small vessels, in order to reduce organ failure.
- Detailed Description
In a single-center open label study we evaluated the effects of magnesium sulphate (MgS) infusion on the sublingual microcirculation perfusion in fluid resuscitated patients with severe sepsis and septic shock within the first 48 hours after ICU admission. Directly prior to and after 1 hour of magnesium sulphate (MgS) infusion (2 gram) systemic hemodynamic variables, sublingual SDF images and standard laboratory tests, were obtained.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 14
- severe sepsis and septic shock
- pregnancy
- oral bleeding
- age < 18 years
- liver cirrhosis
- acute arrhythmias
- advanced malignancy or a mean arterial pressure (MAP) < 65 mmHg refractory to vasopressors
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description severe sepsis and septic shock Magnesium Sulfate -
- Primary Outcome Measures
Name Time Method microvascular flow index 1 hour Directly prior to and after 1 hour of magnesium sulphate (MgS) infusion (2 gram) systemic hemodynamic variables, sublingual SDF images and standard laboratory tests, were obtained.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hospital of Lithuanian university of health sciences
🇱🇹Kaunas, Lithuania