Study of the Impact of Changes in Carbonemia on Microcirculation in Patients Achieving a Test Hypercapnia

Not Applicable

Completed

• Conditions: Microcirculation; Blood Circulation
• Interventions: Device: confocal microscopy

• Registration Number: NCT02549378
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

The microcirculatory alterations is common in circulatory failure, especially during sepsis. The severity of these changes and their sustainability are responsible of multi organ failure and ultimately death. The optimization of microcirculatory flow could be a central objective of the management of patients hospitalized in intensive care.

Microcirculation includes all blood vessels of a diameter smaller than 100 micrometer. It represents the largest heat exchange surface of the body and is involved in tissue oxygenation. Microcirculatory flow is conditioned by the macrocirculation (heart rate and blood pressure) and the state of the microcirculation (thrombosis, vasoconstriction ...). The role of the CO2 in regulating microcirculatory flow is little studied. A recent work of our team and the oldest work in the literature lead to believe that CO2 has a specific role in modulating microcirculatory flow. No study to date precisely studied the impact of changes in the microcirculatory flow carbonemia .

The hypocapnia test is carried out in a standardized manner by inhalation of a mixture enriched in CO2 7% allows a significant increase in carbonemia. Hypocapnia will in turn obtained by a calibrated voluntary hyperventilation test.

Direct visualization of microcirculation by confocal microscopy is now considered the gold standard for exploring the microcirculation.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-05
• Primary Completion: 2013-06
• Study Completion: 2013-06
• Status Verified: 2015-09
• Study First Submitted: 2015-09-11
• Study First Submitted QC: 2015-09-14
• Last Update Submitted: 2015-09-14
• Study First Posted: 2015-09-15
• Last Update Posted: 2015-09-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

• patients from achieving hypercapnia test the CHU of Saint-Etienne
• non smoking
• non diabetic
• affiliated with or entitled to a social security system
• Written consent

Exclusion Criteria

• subjects not performing the test hypercapnia in full
• patients with dermatological pathology at the study area
• patient with Raynaud's syndrome
• Patients with known bleeding disorders
• refusal to consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
patients with a hypercapnia test	confocal microscopy	confocal microscopy patients with a hypercapnia test

Primary Outcome Measures

Name	Time	Method
microcirculatory flow (cells / min) measured by confocal microscopy	Day1	microcirculatory flow (cells / min) measured by confocal microscopy in hypocapnic patients

Secondary Outcome Measures

Name	Time	Method
microvessel diameter (micrometer) measured by confocal microscopy	Day1	microvessel diameter (micrometer) measured by confocal microscopy in hypocapnic patients

Trial Locations

Locations (1)

CHU Saint-Etienne; 🇫🇷 Saint-Etienne, France