To evaluate add on effect of hydroxyethyl starch with lignocaine for pain relief following propofol administration

Propofol is the most widely used intravenous induction agent in anaesthesia. Pain on propofol injection is a common problem.Even with multimodal techniques,pain on propofol injection is not abolished completely. Hydroxyethyl Starch(HES),a colloid,is a clinically safe and well tolerated complex polysaccharide and has the capacity to modify endothelial cell junctions and permeablity of the vascular endothelium.Pre administration of HES may prevent contact activation of propofol which may in turn lead to reduced pain during propofol injection.A prospective,double blind,randomized study will be conducted on a total of 206 ASA I and II patients of age 18-65 yrs undergoing elective surgery under general anaesthesia who will be randomly allocated into group ’H’ and ’S’ of 103 each. Patients in group ’H’ will be administered 50 ml of 6% HES with 2% lignocaine(1mg/kg) while patients in group ’S’ will be administerd equal volume of 0.9% saline with 2% lignocaine 2mins before induction with 1% propofol(2mg/kg).The incidence and severity of pain on propofol injection will be calculated using Numerical Pain Rating Scale every 15 secs till loss of verbal command. Our aim of the study is to compare the incidence and severity of pain on propofol injetion pre administered with 6%HES with 2% lignocaine or 0.9% saline with 2% lignocaine during induction of anaesthesia.